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News Prim. MUDr. Gustáv Ondrejka: Biological treatment of asthma eliminates the need for systemic corticotherapy

Despite advances in the therapy of bronchial asthma, a portion of patients still do not achieve the desired control of the disease. The introduction of biological treatment marked a significant milestone in management, improving the prognosis for patients previously dependent on long-term systemic corticotherapy with all its negative impacts. The recently approved reimbursement for dupilumab expands treatment options for patients with severe asthma, relieving patients of common asthma comorbidities. The current perspective on the treatment of bronchial asthma is provided by the head of the Pulmonary Department at KNTB Zlín, which includes the Center for the Diagnosis and Treatment of Severe Forms of Bronchial Asthma, Prim. MUDr. Gustáv Ondrejka, Ph.D.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 18. 4. 2022

News Benefits of Combining Olopatadine and Mometasone in the Treatment of Allergic Rhinitis

Ryaltris is indicated for adults and adolescents aged 12 years and older for the treatment of moderate to severe nasal symptoms associated with allergic rhinitis (AR). The active ingredient of the preparation is a fixed combination of locally acting antihistamine olopatadine hydrochloride and corticosteroid mometasone furoate. Its efficacy and safety have been confirmed by numerous clinical studies, compared to placebo, as well as other drugs used in the treatment of AR.

Source: Life Without Allergic Rhinitis 27. 4. 2022

News MUDr. Marek Štefan: Cooperation With Pharmacists Is Essential in Antibiotic Therapy

In September, the Congress of Clinical Microbiology, Infectious Diseases and Epidemiology (KMINE) took place in Hradec Králové. What insights did it bring regarding current and emerging antibiotic therapy? And how might the discussed conclusions translate into everyday antibiotic prescribing? MUDr. Marek Štefan, MBA, from the Department of Infectious Diseases and Travel Medicine, 2nd Faculty of Medicine, Charles University, and Motol University Hospital in Prague, shared his observations on these topics.

Source: 10. 11. 2025

News Comparison of Clinical Outcomes of TKA Implantation: ATTUNE vs. SIGMA

The ATTUNE total knee arthroplasty (TKA) system was introduced to the market in 2013 as a successor to the popular SIGMA system. The new type of knee endoprosthesis is designed to provide better stability and mobility than the previous implant. Several studies have evaluated the clinical outcomes of the implantation of both types of endoprostheses.

Source: Large Joints 7. 2. 2020

News How to Properly Treat Frostbite?

Frostbite, or congelation, is defined as an acute condition involving damage to the skin and subcutaneous tissues due to local cold, particularly at subzero temperatures. Treatment requires quality care. By choosing the right therapy, we can prevent complications that might otherwise threaten the patient with amputation of the affected part. The healing process is lengthy and requires patience from both the patient and the attending physician.

Source: Wound Healing 7. 12. 2021

News Epstein-Barr Virus –⁠ Is the Culprit of MS Revealed?

Could the Epstein-Barr virus hold the answer to the etiology of multiple sclerosis? A dataset of over 10 million American recruits offered intriguing insights. You may have encountered the conclusions of one of the most extensive studies in modern history in the media. Let's take a closer look at the work of Kjetil Bjornevik and his colleagues.

Source: Multiple Sclerosis 23. 5. 2022

News Reimbursement vs. Indication: Are They Clashing in Alzheimer's Disease?

Data from clinical trials and recommended procedures do not always align with insurance reimbursement criteria. Is this the case with Alzheimer's disease treatment?

Source: Cognitive in the treatment of Alzheimer's disease 17. 5. 2020

News Key for Patients with PBC are Timely Diagnosis and Assessment of Therapy Effectiveness

Primary biliary cholangitis (PBC) cannot be cured. It progresses slowly and over several decades leads to liver cirrhosis with all its potential consequences, including possible transplantation and the risk of premature death. The foundation of PBC pharmacotherapy is ursodeoxycholic acid (UDCA) and in recent years, obeticholic acid (OCA) has also been available, which European and Czech guidelines recommend as the second-line treatment. One of the symposiums at this year's XLVIII May Hepatology Days also focused on PBC and its therapy, including experiences from Czech practice.

Source: Primary Biliary Cholangitis 19. 7. 2021

News Metformin in Pregnancy and Its Safety Profile

In Finland, a comprehensive analysis of data from the national registry was conducted to assess whether exposure to metformin during intrauterine development is associated with an increased risk of long-term or short-term health problems.

Source: Modern Treatment of Diabetes 6. 6. 2022

News American Heart Association: Side Effects of Statins Overview and Context

The American Heart Association (AHA) report provides an updated summary of knowledge on the safety of statin use. Despite warnings appearing in professional literature and general media, it assures that statins are an effective and safe modality for treating hypercholesterolemia.

Source: Cardiovascular Risks 15. 4. 2020

News Urinary Incontinence in Old Age as the Most Frequent Medical Problem

In patients over 65 years of age, incontinence occurs more frequently than cancer or cardiovascular diseases. Urine leakage significantly reduces the quality of life for seniors, worsens their overall health, and isolates them from society. Therefore, doctors should participate in destigmatizing this problem and actively offer their help to seniors and their family members.

Source: Incontinence 9. 9. 2020

News Thanks to Buccolam, the reality of suppressing convulsive seizures in children and adolescents approaches parents' ideal management

What crosses the mind of a parent when they notice their epileptic child or adolescent is having a convulsive seizure? They want it to be over quickly and safely. What constitutes the integral part that makes this wish a reality? And how does the newest treatment modality, buccally administered midazolam (Buccolam), address these needs?

Source: Quick aid for acute convulsive seizures in children and adolescents 25. 10. 2023

News Prediction of Hypocalcemia Risk in Patients Treated with Denosumab and Active Form of Vitamin D

According to new work by Japanese authors, it appears that the risk factors for the development of hypocalcemia in patients treated with denosumab and calcitriol (the active form of vitamin D) are different from those when natural vitamin D is added to denosumab.

Source: Prevention of Bone Events 8. 6. 2023

News Effective antiosteoporotics from the aminobisphosphonate group can finally be prescribed by general practitioners from January 2024

Osteoporosis represents a serious societal problem generating numerous health and social complications as well as considerable economic costs. In the Czech Republic, it is estimated to affect 500−750 thousand people, or 5−7% of the population. From January 1, 2024, the prescription restriction for the indication and reimbursement conditions for the medicinal products Osagrand (ibandronic acid) and Risendros (risedronic acid) will be lifted, allowing general practitioners to prescribe them as well, under the prescription conditions listed below.

Source: Treatment of Osteoporosis 12. 12. 2023

News Pregabalin in Seniors Confirmed Its Safety and Effectiveness

A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in the general population sample?

Source: Neuropathic Pain 25. 6. 2020