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News With Prof. Pavel Žák about Current Trends and Future Perspectives in Bone Marrow Transplantation and the Role of Carmustine in this Context

Hematopoietic stem cell transplantation has an indispensable place in the treatment of hemato-oncological diseases. We discuss current trends in this area, the significance and benefits of carmustine, the choice between BEAM and TEAM regimens, and the future of bone marrow transplantation in the context of new technologies with the head of the 4th Department of Hematology of the Faculty of Medicine, Charles University and University Hospital Hradec Králové, Prof. MUDr. Pavel Žák, Ph.D.

Source: Oncological Treatment 10. 6. 2024

News Fixed Combination of Candesartan/Amlodipine in the Treatment of Arterial Hypertension

Arterial hypertension is a significant cardiovascular risk factor. A variety of antihypertensives are used in therapy, both in monotherapy and combination treatment. Often, it is necessary to treat patients with a combination of multiple antihypertensives to achieve satisfactory blood pressure values. A popular fixed combination with a favorable pharmacodynamic and pharmacokinetic profile is the combination of candesartan and amlodipine, whose effects have been verified by numerous extensive clinical studies.

Source: Sartans in the Treatment of Hypertension 19. 1. 2021

News Combination of Arterial Hypertension and Increased Heart Rate as a Significant Cardiovascular Risk Factor

Heart rate is one of the basic vital signs that should be regularly measured. Sinus tachycardia can be physiological under certain conditions. However, a patient with resting tachycardia should always be examined, as tachycardia can be a symptom of a serious health problem. Especially in patients with arterial hypertension, a rapid heart rate significantly increases cardiovascular risk.

Source: Cardiovascular Continuum 23. 11. 2020

News Effectiveness of the Sonicare For Kids Toothbrush in Preschool Children

A comparative study conducted as part of a graduation thesis in the field of Certified Dental Hygienist offers a comparison of the cleaning effectiveness of a manual toothbrush and a sonic toothbrush in children aged 4−5.5 years. The sonic toothbrush proved to be an effective tool with good results for this age group.

Source: Dental Care 15. 10. 2023

News Levothyroxine and the Interchangeability of Preparations Containing It

Levothyroxine is a synthetic thyroid hormone used to treat patients with hypothyroidism, which affects approximately 1-2% of the younger population and increases with age, especially in women. Levothyroxine is a drug with a narrow therapeutic window, and its bioavailability is influenced by many factors, including consumed foods, medications, and beverages.

Source: Thyroid Disorders 6. 11. 2020

News Prostate Health Index and its Possible Use in Clinical Practice

With the increasing incidence of prostate cancer, the effort to improve its diagnostics is also growing. The exclusively used and practice-proven prostate-specific antigen (PSA) continues to play an indispensable role in identifying at-risk patients, but some of its isoforms can also provide important information for deciding the patient's further fate. Based on their combination, a so-called prostate health index (PHI) can be determined. A recently published work by Czech authors assessed the usability of PHI as a parameter suitable for evaluating the aggressiveness of prostate cancer (PC) within the PHIMOPLUKTHOM study.

Source: Prostate Health Index 9. 11. 2020

News Effectiveness of Arginine in Tooth Cleaning Proven (Not Only) by Quantitative Light-Induced Fluorescence

There is no doubt about the benefits of toothpaste in daily dental care. Today, there are numerous studies proving that brushing without toothpaste does not have the same effectiveness as brushing with toothpaste. It is more effective and, thanks to active ingredients, can slow down or even reverse the development of tooth decay.

Source: Dental Caries 4. 5. 2020

News Maintenance Therapy of a Female Patient with AML After Intense Chemotherapy –⁠ Case Study

The following case study presents the case of a female patient with acute myeloid leukemia (AML) who experienced life-threatening complications after the second consolidation chemotherapy, rendering her incapable of undergoing further intense therapy or allogeneic HSCT. In this situation, maintenance therapy with oral azacitidine proved beneficial –⁠ this modality, due to its good tolerance, can be used as a bridge until allo-HSCT can be performed in patients in poor clinical condition.

Source: Acute Myeloid Leukemia 10. 5. 2024

News Pregabalin in the Hands of a General Practitioner

A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy –⁠ conditions that general practitioners frequently encounter in their practice. Is pregabalin a suitable choice in these indications?

Source: Neuropathic Pain 18. 2. 2020

News Incontinence Dermatitis -⁠ Common, Yet Often Overlooked Diagnosis

Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis. It causes significant discomfort to patients and can also require difficult and prolonged treatment.

Source: Incontinence 21. 4. 2020

News The Brain, Too, Has Its Midlife Crisis. How Do These Changes Relate to the Risk of Dementia in Old Age?

The human brain undergoes rapid changes during certain developmental periods. Childhood, adolescence, and advanced old age undoubtedly belong to these. For much of adulthood, it seems that nothing much actually happens. However, it turns out that the brain’s clock begins to accelerate around 40–50 years of age. What impact do these gradual changes have on our future health?

Source: 31. 10. 2024

Články časopisu The importance of oral hygiene in the prevention of plaque induced oral cavity diseases

Author of the article: M. Nedvědová Source: Praktický lékař | 3/2008 31. 3. 2008

News Prediction of Cancer Aggressiveness: Prostate Health Index (PHI) as a Promising Future Marker

The Prostate Health Index (PHI) is a diagnostic blood test that combines the levels of prostate-specific antigen (PSA), free PSA (fPSA), and the isoform [-2]proPSA (p2PSA). Its use in prostate cancer diagnostics can reduce the number of unnecessary prostate biopsies compared to determining PSA alone. A recently published Czech study assessed the utility of PHI in evaluating the aggressiveness of prostate cancer. The study compared PHI values with the results of preoperative biopsy and postoperative prostate histology in men indicated for radical prostatectomy.

Source: Prostate Health Index 2. 2. 2020

Články časopisu Hand osteoarthritis

Author of the article: prof. MUDr. Ph.D. Ladislav Šenolt Source: Časopis lékařů českých | 6/2016 9. 11. 2016

News Metamizole at a Glance and in Practice –⁠ Effective Non-Opioid Analgesic for All Ages

The regular webinar of the General Medicine Society of ČLS JEP this spring, besides addressing the current coronavirus situation, also focused on the issue and treatment of pain in its specialized section. Anesthesiologist MUDr. Jan Lejčko from the Pain Treatment Center at KARIM LF UK and FN Plzeň, Vice-President of the Society for the Study and Treatment of Pain ČLS JEP, concentrated on types of pain and principles and options of treatment, particularly using metamizole, in his lecture.

Source: Analgesia 15. 9. 2021