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News Effectiveness of Arginine in Tooth Cleaning Proven (Not Only) by Quantitative Light-Induced Fluorescence

There is no doubt about the benefits of toothpaste in daily dental care. Today, there are numerous studies proving that brushing without toothpaste does not have the same effectiveness as brushing with toothpaste. It is more effective and, thanks to active ingredients, can slow down or even reverse the development of tooth decay.

Source: Dental Caries 4. 5. 2020

News Maintenance Therapy of a Female Patient with AML After Intense Chemotherapy –⁠ Case Study

The following case study presents the case of a female patient with acute myeloid leukemia (AML) who experienced life-threatening complications after the second consolidation chemotherapy, rendering her incapable of undergoing further intense therapy or allogeneic HSCT. In this situation, maintenance therapy with oral azacitidine proved beneficial –⁠ this modality, due to its good tolerance, can be used as a bridge until allo-HSCT can be performed in patients in poor clinical condition.

Source: Acute Myeloid Leukemia 10. 5. 2024

News Pregabalin in the Hands of a General Practitioner

A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy –⁠ conditions that general practitioners frequently encounter in their practice. Is pregabalin a suitable choice in these indications?

Source: Neuropathic Pain 18. 2. 2020

News Incontinence Dermatitis -⁠ Common, Yet Often Overlooked Diagnosis

Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis. It causes significant discomfort to patients and can also require difficult and prolonged treatment.

Source: Incontinence 21. 4. 2020

Články časopisu The importance of oral hygiene in the prevention of plaque induced oral cavity diseases

Author of the article: M. Nedvědová Source: Praktický lékař | 3/2008 31. 3. 2008

News Prediction of Cancer Aggressiveness: Prostate Health Index (PHI) as a Promising Future Marker

The Prostate Health Index (PHI) is a diagnostic blood test that combines the levels of prostate-specific antigen (PSA), free PSA (fPSA), and the isoform [-2]proPSA (p2PSA). Its use in prostate cancer diagnostics can reduce the number of unnecessary prostate biopsies compared to determining PSA alone. A recently published Czech study assessed the utility of PHI in evaluating the aggressiveness of prostate cancer. The study compared PHI values with the results of preoperative biopsy and postoperative prostate histology in men indicated for radical prostatectomy.

Source: Prostate Health Index 2. 2. 2020

Články časopisu Hand osteoarthritis

Author of the article: prof. MUDr. Ph.D. Ladislav Šenolt Source: Časopis lékařů českých | 6/2016 9. 11. 2016

News Metamizole at a Glance and in Practice –⁠ Effective Non-Opioid Analgesic for All Ages

The regular webinar of the General Medicine Society of ČLS JEP this spring, besides addressing the current coronavirus situation, also focused on the issue and treatment of pain in its specialized section. Anesthesiologist MUDr. Jan Lejčko from the Pain Treatment Center at KARIM LF UK and FN Plzeň, Vice-President of the Society for the Study and Treatment of Pain ČLS JEP, concentrated on types of pain and principles and options of treatment, particularly using metamizole, in his lecture.

Source: Analgesia 15. 9. 2021

Články časopisu Cutaneous and Mucosal Candidoses

Author of the article: I. Kuklová Source: Česko-slovenská dermatologie | 2/2015 17. 6. 2015

News Minimum and Optimal Factor Levels in Physically Active Hemophiliacs

Authors of a recently published study attempted to determine the value of minimum and optimal levels of coagulation factors in patients with severe hemophilia who engage in physical activities.

Source: Hemophilia 2. 7. 2020

News CASE STUDY: Surgical Procedure in an Adolescent Patient with Severe Hemophilia A on Emicizumab Prophylaxis

This case study is narrated by MUDr. Bohumír Blažek from the Clinic of Pediatric Medicine at LF OU and FN Ostrava. The patient is a 17-year-old boy with severe hemophilia A. Several months prior to the procedure under discussion, he was switched from prophylactic factor VIII administration to emicizumab prophylaxis. Subsequently, an extraction of all four molars was planned for orthodontic reasons. The case study describes the hematologist's approach to the procedure and the subsequent healing process.

Source: Quality Life Even with Hemophilia 1. 2. 2022

News Scientists Decipher the Perception of Bitter Taste. How Will This Help in the Development of New Drugs?

Taste receptors are a known phenomenon, but how exactly does taste perception occur? Scientists from the University of North Carolina focused on bitter taste, as it often accompanies medications. They hope their research will allow the application of their findings, for example, in the development of treatments for obesity or diabetes mellitus (DM).

Source: 29. 11. 2024

News Prim. MUDr. Gustáv Ondrejka: Biological treatment of asthma eliminates the need for systemic corticotherapy

Despite advances in the therapy of bronchial asthma, a portion of patients still do not achieve the desired control of the disease. The introduction of biological treatment marked a significant milestone in management, improving the prognosis for patients previously dependent on long-term systemic corticotherapy with all its negative impacts. The recently approved reimbursement for dupilumab expands treatment options for patients with severe asthma, relieving patients of common asthma comorbidities. The current perspective on the treatment of bronchial asthma is provided by the head of the Pulmonary Department at KNTB Zlín, which includes the Center for the Diagnosis and Treatment of Severe Forms of Bronchial Asthma, Prim. MUDr. Gustáv Ondrejka, Ph.D.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 18. 4. 2022

News Benefits of Combining Olopatadine and Mometasone in the Treatment of Allergic Rhinitis

Ryaltris is indicated for adults and adolescents aged 12 years and older for the treatment of moderate to severe nasal symptoms associated with allergic rhinitis (AR). The active ingredient of the preparation is a fixed combination of locally acting antihistamine olopatadine hydrochloride and corticosteroid mometasone furoate. Its efficacy and safety have been confirmed by numerous clinical studies, compared to placebo, as well as other drugs used in the treatment of AR.

Source: Life Without Allergic Rhinitis 27. 4. 2022

News MUDr. Marek Štefan: Cooperation With Pharmacists Is Essential in Antibiotic Therapy

In September, the Congress of Clinical Microbiology, Infectious Diseases and Epidemiology (KMINE) took place in Hradec Králové. What insights did it bring regarding current and emerging antibiotic therapy? And how might the discussed conclusions translate into everyday antibiotic prescribing? MUDr. Marek Štefan, MBA, from the Department of Infectious Diseases and Travel Medicine, 2nd Faculty of Medicine, Charles University, and Motol University Hospital in Prague, shared his observations on these topics.

Source: 10. 11. 2025