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News Anabolic Antiosteoporotic Treatment as a First Step in Patients with Very High Fracture Risk

According to the 2022 opinion of the ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases) working group, it is advisable to identify patients with osteoporosis who have a very high risk of fracture and to use an anabolic antiosteoporotic drug as the initial pharmacotherapeutic intervention, followed by necessary antiresorptive treatment to be addressed over the entire expected length of life.

Source: Osteoporosis – Trends in Sequential Therapy 18. 1. 2024

News Long-term Keto Diet May Damage Our Organs

Source: 5. 12. 2024

News Use of Targeted Therapy with Dupilumab in Patients with Allergic Diseases

Interleukins (IL) 4 and 13 play an important role in the pathogenesis of allergic diseases. Their blockade is therefore a suitable strategy for a number of these conditions. This is offered by the new monoclonal antibody dupilumab (Dupixent), which is approved for the treatment of atopic dermatitis, asthma with type 2 inflammation, and chronic rhinosinusitis with nasal polyposis. Studies are ongoing to evaluate its efficacy in other diseases where type 2 inflammation predominates.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 11. 10. 2020

News Effect of Prostaglandin Analogues With and Without Preservatives on Meibomian Glands in Glaucoma Patients

Prostaglandin analogues (PGA) have become a standard in the treatment of open-angle glaucoma. However, their long-term use may be associated with eye irritation or damage to the Meibomian glands. The study presented below aimed to determine whether these changes are directly caused by PGAs or the preservatives in the eye drops.

Source: Treatment of Glaucoma 31. 3. 2021

News Interactive Case Study: Treatment of Neuropathic Pain in a Patient with Neurodegenerative Disease

We offer a brief case study of a polymorbid patient suffering from chronic pain, spasticity, and sleep disturbances, among other issues. Medical cannabis was advantageously introduced, helping to alleviate several symptoms. You can interactively explore how you would proceed in this case.

Source: Medical Cannabis 22. 4. 2024

News MUDr. Jana Zárubová: Experiences with buccal midazolam in real practice are positive and we can significantly improve patients' quality of life

Recently, it has emerged as an alternative to traditionally rectally administered diazepam for stopping prolonged convulsive seizures in patients with epilepsy. What can buccal midazolam offer them and how has it proven itself in real practice? MUDr. Jana Zárubová from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague describes.

Source: Quick aid for acute convulsive seizures in children and adolescents 21. 2. 2024

News AI Could Transform Cancer Treatment by Precisely Identifying Tumor Cells

A new artificial intelligence tool called AAnet, developed and tested by researchers led by the Garvan Institute of Medical Research, focuses on the cellular diversity within individual tumors. Deeper understanding of the different types of cells present in tumors could pave the way for therapies more accurately tailored to individual patients.

Source: 10. 9. 2025

News Medication in Patients with Myasthenia Gravis –⁠ What to Watch Out For?

According to current recommendations, the treatment of myasthenia gravis (MG) should be individualized, considering the severity of the disease, the type of autoantibodies, thymus pathology, and, last but not least, the patient's preferences and comorbidities. What are the usual treatment modalities? What specifics need to be considered when treating comorbidities or acute illnesses in patients with MG? The following text briefly summarizes the answers to these questions.

Source: Rare Diseases in Neurology 29. 6. 2023

News Oral Azacitidine After Achieving Remission in AML Improves Survival and Does Not Worsen Quality of Life

Orally administered azacitidine as maintenance therapy in patients with acute myeloid leukemia (AML) after achieving remission provides a favorable effect in terms of fatigue and improving health-related quality of life (HRQoL). This is based on the results of the QUAZAR AML-001 study, which were published in the journal Haematologica.

Source: Acute Myeloid Leukemia 10. 10. 2023

News What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?

A Spanish clinical study monitored the effect of administering probiotics as an adjunct therapy to non-surgical mechanical treatment of peri-implantitis. What did the study show regarding the effect on microbiome composition and overall clinical picture when a preparation containing Limosilactobacillus reuteri Prodentis was administered?

Source: Dental Care 7. 6. 2024

News Hypnotics in the Therapy of Insomnia (Not Only) in the Elderly

Problems with insomnia make up a significant part of the subjective complaints, especially of older patients in our clinics. Up to 1/3 of the population may suffer from chronic insomnia symptoms, and the number of people with this problem is continuously increasing. What are our options in its treatment?

Source: Geriatric Patient 25. 5. 2020

Články časopisu Proximal tibiofibular joint dislocation -⁠ Case report

Author of the article: Eva Čurlejová, Petr Špiroch, Pavel Dráč, Jan Hrbek Source: Úrazová chirurgie | 4/2016 19. 12. 2016

News Prof. Hana Rosolová: According to recent studies, caution is needed with beta-blockers only in severe cases of asthma and COPD

Beta-blockers (BB) are among the most widely used drug groups in cardiology. While their position is clear in some indications, it is debated in others. Additionally, individual BBs differ in various aspects, which plays an important role in selecting the right treatment for a particular patient. We discussed some current topics related to beta-blockers with the head physician of the Center for Preventive Cardiology of the 2nd Department of Internal Medicine LF UK and FN Plzeň Prof. MUDr. Hana Rosolová, DrSc., FESC.

Source: Cardiovascular Continuum 23. 11. 2023

News Stabilization of Transthyretin and Long-term Survival of Patients with Cardiac Amyloidosis

Tafamidis is used in the therapy of transthyretin amyloid cardiomyopathy (ATTR-CM), which has proven its benefit in the ATTR-ACT clinical study. The results of its open-label extension study show that early diagnosis and prompt initiation of therapy are crucial.

Source: Amyloidosis 20. 11. 2023

News Efficacy of Hyaluronic Acid Eye Drops in the Treatment of Dry Eye Syndrome –⁠ Results of a Meta-Analysis

Dry eye syndrome affects 5–30% of individuals over the age of 50. The beneficial effect of hyaluronic acid on the symptoms of this condition has been well described in both preclinical and clinical studies, and it has been shown that its topical application increases the secretion of water and mucin on the surface of the eye. The meta-analysis presented below focused on the efficacy of eye drops containing hyaluronic acid in the treatment of dry eye syndrome.

Source: Ophthalmologic Diseases 13. 3. 2023