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News MUDr. Jana Zárubová: Experiences with buccal midazolam in real practice are positive and we can significantly improve patients' quality of life

Recently, it has emerged as an alternative to traditionally rectally administered diazepam for stopping prolonged convulsive seizures in patients with epilepsy. What can buccal midazolam offer them and how has it proven itself in real practice? MUDr. Jana Zárubová from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague describes.

Source: Quick aid for acute convulsive seizures in children and adolescents 21. 2. 2024

News AI Could Transform Cancer Treatment by Precisely Identifying Tumor Cells

A new artificial intelligence tool called AAnet, developed and tested by researchers led by the Garvan Institute of Medical Research, focuses on the cellular diversity within individual tumors. Deeper understanding of the different types of cells present in tumors could pave the way for therapies more accurately tailored to individual patients.

Source: 10. 9. 2025

News Medication in Patients with Myasthenia Gravis –⁠ What to Watch Out For?

According to current recommendations, the treatment of myasthenia gravis (MG) should be individualized, considering the severity of the disease, the type of autoantibodies, thymus pathology, and, last but not least, the patient's preferences and comorbidities. What are the usual treatment modalities? What specifics need to be considered when treating comorbidities or acute illnesses in patients with MG? The following text briefly summarizes the answers to these questions.

Source: Rare Diseases in Neurology 29. 6. 2023

News Oral Azacitidine After Achieving Remission in AML Improves Survival and Does Not Worsen Quality of Life

Orally administered azacitidine as maintenance therapy in patients with acute myeloid leukemia (AML) after achieving remission provides a favorable effect in terms of fatigue and improving health-related quality of life (HRQoL). This is based on the results of the QUAZAR AML-001 study, which were published in the journal Haematologica.

Source: Acute Myeloid Leukemia 10. 10. 2023

News What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?

A Spanish clinical study monitored the effect of administering probiotics as an adjunct therapy to non-surgical mechanical treatment of peri-implantitis. What did the study show regarding the effect on microbiome composition and overall clinical picture when a preparation containing Limosilactobacillus reuteri Prodentis was administered?

Source: Dental Care 7. 6. 2024

News Hypnotics in the Therapy of Insomnia (Not Only) in the Elderly

Problems with insomnia make up a significant part of the subjective complaints, especially of older patients in our clinics. Up to 1/3 of the population may suffer from chronic insomnia symptoms, and the number of people with this problem is continuously increasing. What are our options in its treatment?

Source: Geriatric Patient 25. 5. 2020

Články časopisu Proximal tibiofibular joint dislocation -⁠ Case report

Author of the article: Eva Čurlejová, Petr Špiroch, Pavel Dráč, Jan Hrbek Source: Úrazová chirurgie | 4/2016 19. 12. 2016

News Stabilization of Transthyretin and Long-term Survival of Patients with Cardiac Amyloidosis

Tafamidis is used in the therapy of transthyretin amyloid cardiomyopathy (ATTR-CM), which has proven its benefit in the ATTR-ACT clinical study. The results of its open-label extension study show that early diagnosis and prompt initiation of therapy are crucial.

Source: Amyloidosis 20. 11. 2023

News Efficacy of Hyaluronic Acid Eye Drops in the Treatment of Dry Eye Syndrome –⁠ Results of a Meta-Analysis

Dry eye syndrome affects 5–30% of individuals over the age of 50. The beneficial effect of hyaluronic acid on the symptoms of this condition has been well described in both preclinical and clinical studies, and it has been shown that its topical application increases the secretion of water and mucin on the surface of the eye. The meta-analysis presented below focused on the efficacy of eye drops containing hyaluronic acid in the treatment of dry eye syndrome.

Source: Ophthalmologic Diseases 13. 3. 2023

News Profile of the effect of aclidinium bromide compared to glycopyrronium bromide

A study by Spanish authors examined the profiles of 2 long-acting muscarinic receptor antagonists (LAMA), aclidinium bromide and glycopyrronium bromide, under in vitro and in vivo conditions.

Source: Treatment of Asthma and COPD 29. 3. 2021

News Dupilumab Now Covered for Atopic Dermatitis in Children Older Than 6 Years

Dupilumab is now fully covered by public health insurance for pediatric patients from 6 years old with atopic dermatitis. This opens up a new possibility for pediatric patients with this condition to improve their quality of life.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 22. 1. 2022

Články časopisu Prevention of TEN in surgery, prolonged thromboprophylaxis

Author of the article: Z. Krška Source: Rozhledy v chirurgii | 5/2012 30. 5. 2012

News Current Approaches to COPD Therapy According to GOLD Recommendations and in the Conditions of Czech Practice

Chronic Obstructive Pulmonary Disease (COPD) represents a significant global cause of morbidity and mortality with a high prevalence that is expected to increase significantly in the coming years. Since it is a preventable and treatable disease, active therapy, which is globally guided by international recommendations based on the GOLD strategy, plays an important role. However, in the following article, we will also place these recommendations in the current context of care for these patients in the Czech Republic.

Source: Treatment of Asthma and COPD 15. 11. 2022

News Anticoagulants and Antiplatelets in the Treatment of Acute Coronary Syndromes

Anticoagulants and antiplatelets are a key part of the therapeutic strategies used in the treatment of acute coronary syndromes (ACS). They reduce the risk of acute and late complications, morbidity, and mortality in patients. On the other hand, their main disadvantage is the potential occurrence of bleeding complications. Therefore, the goal of physicians is to use these medications appropriately, maximizing benefits for patients while minimizing the risk of bleeding.

Source: Thromboprophylaxis 13. 6. 2022

News Current Recommendations by the ELN Expert Panel on AML Diagnosis Management

The 2022 recommendations from European LeukemiaNet (ELN) add new information to the previous recommendations from 2010 and 2017. They concern the diagnosis and treatment of acute myeloid leukemia (AML) in adults from the perspective of pathogenesis, disease classification adjustment, possibilities of genomic diagnosis, and the inclusion of minimal residual disease (MRD) assessment.

Source: Acute Myeloid Leukemia 9. 5. 2023