B-cell chronic lymphocytic leukemia Part II: Diagnostic criteria and the importance of individual patient’s prognosis assessment
T. Papajík; M. Jarošová; Z. Pikalová; K. Indrák
Hemato-onkologická klinika FN a LF UP v Olomouci
Transfuze Hematol. dnes,12, 2006, No. 3, p. 132-139.
Comprehensive Reports, Original Papers, Case Reports
B-cell chronic lymphocytic leukemia (B-CLL) represents most common leukemia in Western Europe and North America adult population. Accurate diagnosis of the disease based on leukemic cell immunophenotype analysis has principal importance in differential diagnostic distinction of B-CLL from other leukemized B-cell malignancies. Determination of strong and independent prognostic parameters in early and intermediate disease stage patients could lead to consideration of appropriate therapeutic approach. Assessment of IgVH mutational status, ZAP70 and CD38 expression levels, genetic aberrations and p53 gene mutations constitute modern tools for understanding of biologic behavior and potential aggressiveness of leukemic clone.
B-cell chronic lymphocytic leukemia, diagnosis, immunocytology, cytogenetic, IgVH mutations, prognosis
Plasma concentrations of cytokines and co-stimulatory molecules (interleukins IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, TNF-α, TGFβ1, sCD23, sCD40L and IL-6 receptor) in healthy blood donors