Post menopausal osteoporosis – „dysmobility syndrome“

Authors: Jiří Jenšovský
Authors‘ workplace: Interní klinika 1. LF UK a ÚVN – Vojenská fakultní nemocnice Praha-Střešovice, Osteocentrum
Published in: Prakt Gyn 2015; 19(2): 127-130
Category: Climacteric medicine: Review article


Osteoporosis, an accompanying problem of the postmenopausal period, needs to be rather considered as “perignosis“ and understood more broadly in relation to sarcopenia as a symptom of ageing of the organism. A new term “dysmobility syndrome“ attempts to reflect this factor. The main therapeutic measure, apart from supplementing vitamin D and administering osteoporotic preparations, must be the provision of appropriate and sufficient physical exercise.

Key words:
frailty syndrome – osteoporosis – physical activity – sarcopenia


1. Cooper C, Dere W, Evans W et al. Frailty and sarcopenia: definitions and outcome parameters. Osteoporos Int 2012; 23(7): 1839–1848.

2. Cruz- Jentoft AJ, Baeyens JP, Bauer JM et al. Sarcopenia: european consensus on definition and diagnosis. Age and Ageing 2010; 39(4): 412–423.

3. Topinkova E. Aging, disability and frailty. Ann Nutr Metab 2008; 52(Suppl 1): S6-S11.

4. Masud T, Binkley N, Boonen S et al. Official positions for FRAX clinical regarding falls and frailty: Can falls and frailty be used in FRAX? J Clinical Densitometry 2011; 14(3): 194–204.

5. Leslie WD, Lix LM. Comparison between various fracture risk assesment tools. Osteoporos Int 2014; 25(1): 1–21.

6. Leavy B, Aberg AC, Melhus H et al. When and where do hip fractures occur? Osteoporos Int 2013; 24(9): 2387–2396.

7. deVries OJ, Peeters GMEE, Lips P et al. Does frailty predict increased risk of falls and fractures? Osteoporos Int 2013; 24(9): 2397–2403.

8. Bischoff-Ferrari HA: Prevention of falls. In: Rosen CJ, Bouillon R (eds). Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th ed. Wiley-Blackwell – ASBMR: 2013: 389–395. ISBN 978–1118453889.

9. Gregson CL, Dennison EM, Compston JE at al. Disease secific perception of fracture risk and incident fracture rates: GLOW cohort study. Osteoporos Int 2014 J; 25(1): 85–95. Dostupné z DOI: <–013- 2438-y>.

10. Tom SE, Adachi JD, Anderson FA et al. Frailty and fracture, disability, and falls: a multiple country study from the Global Longitudinal Study of osteoporosis in women. J Am Geriatr Soc 2013; 61(3): 327–334.

11. Schacht E. Reduction of falls and osteoporotic fractures: plain vitamin D or hormone analogs? Geriatr Gerontol Int 2008; 8(Suppl 1): S16-S25.

12. Richy F, Dukas L, Schacht E. Differential effects of D- hormone analogs and native vitamin D on the risk of falls: a comparative meta anylasis. Calcif Tissue Int 2008; 82(2): 102–107.

13. Dukas L, Schacht E, Mazor T et al. Treatment with alfacalcidol in elderly people significantly decreases the hihg risk of falls associated with a low creatinine clearance of bellow 65 ml/min. Osteoporos Int 2005; 16(2): 198–203.

14. Dukas L, Bischoff HA, Lindpaintner LS et al. Alfacalcidol educes the number of fallers in a community- dwelling elderly population with a minimum calcium intake of more than 500 mg daily. J Am Geriatr Soc 2004; 52(2): 230–236.

15. Fried LP. Frailty in: Halter J, Ouslander J (eds). Hazzards Geriatric Medicine and Gerontology (Principles of Geriatric Medicine & Gerontology). 6th ed. McGraw Hill: 2009: 631- 645. ISBN 978–0071488723.

16. Binkley N, Krueger D, Buehring B. What is in the name revisited: should osteoporosis and sarcopenia be considered components of „dysmobility syndrome?“ Osteoporos Int 2013; 24(12): 2955–2959. Dostupné z DOI: <–013- 2427–1>.

17. Siris ES, Boonen S, Mitchell PJ et al. What is in the name? What constitutes the clinical diagnosis of osteoporosis? Osteoporos Int 2012; 23(8): 2093–2097.

18. Studenski S, Perera S, Patel K et al. Gait speed and survival rate in older adults. JAMA 2011; 305(1): 50–58.

19. Saltvedt I, Prestmo A, Einarsen E et al. Development and delivery of patient treatment in the Trondheim Hip Fracture Trial. A new geriatric in-hospital pathway for elderly patients with hip fracture. BMC Research Notes 2012; 5: 355. Dostupné z DOI: <–0500- 5–355>.

20. Kemmler W, von Stengel S, Bebenek M et al. Exercise and fractures in postmenopausal women: a 12-year results of the Erlangen Fitness and Osteoporosis Prevention Study (EFOPS). Osteoporos Int 2012; 23(4): 1267–1276.

21. Kemmler W, Haberle L, von Stengel S. Effects of exercise on fracture reduction in older adults. Osteoporos Int 2013; 24(7): 1937–1950.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Practical Gynecology

Issue 2

2015 Issue 2

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account