Benefits of norgestimate in combined hormonal contraception

Authors: Tomáš Fait
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. Alois Martan, DrSc.
Published in: Prakt Gyn 2014; 18(3): 178-179
Category: Gynecology and Obstetrics: Review Article


Monophasic combination 250 mg of norgestimate (NGM) plus 35 mg of ethinylestradiol (EE) is conjoined with ideal combination of efficacy, safety and positive noncontraceptive effects. Its priorities are the perfect control of vaginal bleeding and positive antiandrogenic effects without influence on libido.

Key words:
antiandrogenic effect – combined hormonal contraception – libido – norgestimate


1. WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception: Acute myocardial infarction and combined oral contraceptives: results of an international multicentre case-control study. Lancet 1997; 349(9060): 1202–1209.

2. Corson SL. Efficacy and clinical profile of a new oral contraceptive containing norgestimate. US clinical trials. Acta Obstet Gynecol Scand Suppl 1990; 152: 25–31.

3. Kaplan B. Desogestrel, norgestimate, and gestodene: the newer progestins. Ann Pharmacother 1995; 29(7–8): 736–742.

4. Paseková V, Chroust K. Výskyt krvácení u uživatelek kombinované hormonální antikoncepce (etinylestradiol 35 µg /norgestimát 250 µg) v závislosti na pravidelnosti a způsobu zahájení užívání. Čes Gynek 2003; 68(2): 84–88.

5. Arowojolu AO, Gallo MF, Lopez LM, Grimes DA. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev 2012; 7: CD004425. Dostupné z DOI: http://doi: 10.1002/14651858.CD004425.

6. Graham CA, Bandroft J, Doll HA et al. Does oral contraceptive-induced reduction in free testosterone adversely affect the sexuality or mood in women? Psychoneuroendocrinology 2007; 32(3): 246–255.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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