Borderline ovarian tumours


Authors: L. Minář;  H. Al-Awad;  E. Jandáková
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno 1;  Ústav patologie LF MU a FN Brno 2
Published in: Prakt Gyn 2010; 14(3): 123-127
Category: Review Article

Overview

Objective:
To compile an information sheet about borderline ovarian tumors.

Design:
Literature review with case reports.

Setting:
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital, Brno. Methods: Literature review on borderline ovarian tumours with illustrative case reports.

Conclusions:
Borderline ovarian tumours represent 10–15% of all ovarian tumours. They are considered as a separate entity and not as precanceroses of invasive ovarian tumours. They manifest themselves 10–15 years prior to invasive tumours, a higher proportion of tumours is diagnosed at earlier stages, metastatic spread is rare. Serous borderline tumours may be associated with implantation metastases that make the prognosis of the disease worse. Manifestation of the disease at a younger age and lower levels of tumour markers (Ca 125) play an important role in preoperative differential diagnosis between borderline and invasive tumours. Ultrasound examination has an important role in the differential diagnosis of benign and malignant ovarian pathology. Surgical treatment is essential in the primary identification of the disease as well as prevention of recurrence. Since these tumours frequently occur in younger patients, fertility sparing surgery is often required. This operation is characterized by preservation of the uterus and the unilateral adnexa or at least part of one ovary. If both ovaries are affected, the uterus only might be preserved with subsequent inclusion of the patient in an IVF programme with oocyte donation. Following the surgery, patients must be carefully followed up. Removal of the preserved adnexa after the completion of their reproductive plans is recommended in patients who underwent conservative surgery.

Key words:
borderline ovarian tumour – implants metastasis – fertility preserving surgery – ultrasonography examination – lymphadenopathy


Sources

1. Cibula D, Petrželka L et al. Onkogynekologie. Praha: Grada Publishing 2009: 503–508.

2. Eichhorn JH, Bell DA, Young RH et al. Ovarian serous borderline tumors with micropapillary and cribriform patterns: A study of 40 cases and comparison with 44 cases without these patterns. Am J Surg Pathol 1999; 23(4): 397–409.

3. Dundr P. Histopatologická klasifikace nádorů ženského genitálu. Mod Gynek Porod 2007; 16(3): 509–510.

4. Motlík K, Živný J. Patologie v ženském lékařství. Praha: Grada Publishing 2001: 550.

5. Fischerová D. Diagnostika a staging v onkogynekologii. Mod Gynek porod 2007: 16(3): 529–531.

6. Fischerová D. Ultrazvukové zobrazení benigních a maligních ovariálních nádorů. Mod Gynek Porod 2007; 16(4): 752–754.

7. Emoto M, Udo T, Obama H et al. The blood flow characteristics in borderline ovarian tumors based on both color Doppler ultrasound and histopathological analyse. Gynec Oncol 1998; 70(3): 351–357.

8. Fruscella E et al. Ultrasound features of different histopathological subtypes of borderline tumors. UOG 2005; 25: 50.

9. Timmermann D et al. Subjective assessment of adnexal masses with the use of ultrasonography: an analysis of interobserver variability and experience. UOG 1999; 13: 11.

10. Valentin L et al. Ultrasound characteristics of different types of adnexal malignancies. UOG 2006, 102: 41.

11. Camatte S, Morice P, Rey A et al. Impact of surgical staging in patient with macroscopic stage I ovarian borderline tumors: analysis of a continuous series of 101 cases. Eur J Cancer 2004, 40: 1842–1849.

12. Desfeux P, Camatte S, Chatellier G et al. Impact of surgical approach on the management of macroscopic early ovarian borderline tumors. Gynecol Oncol 2005; 98(3): 390–395.

13. Cadron I, Leunen K, Van Gorp T et al. Management of borderline ovarian neoplasm. J Clin Oncol 2007, 25(20): 2928–2937.

14. Morice P. Borderline tumors of the ovary and fertility. Eur J Cancer 2006, 42(2): 149–158.

15. Jančárková N, Krkavcová M, Janashia M et al. Prognostické faktory ovariálního karcinomu. Čes Gynek 2006; 71(3): 252–259.

16. Poncelet C, Fauvet R, Boccara J et al. Recurrence after cystectomy for borderline ovarian tumors: result of a French Multicenter Study. Annals Surg Oncol 2006; 13: 565–571.

17. Silva EG, Gerhenson DM, Malpica A et al. The recurrence and the overall survival rates of ovarian serous borderline neoplasms with noninvasive implants in time dependent. Am J Surg Pathol 2006; 30(11): 1367–1371.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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