Development of vascular substitutes for low-flow peripheral bypass grafting – a review

Authors: P. Mitáš 1;  M. Špaček 1;  T. Grus 1;  H. Chlup 2;  M. Mlček 3;  L. Lambert 4;  M. Krajíček 1;  J. Lindner 1
Authors‘ workplace: II. chirurgická klinika kardiovaskulární chirurgie, Všeobecná fakultní nemocnice a 1. lékařská fakulta Univerzity, Karlovy, Praha 1;  Odbor biomechaniky, Ústav mechaniky, biomechaniky a mechatroniky, Fakulta strojní, ČVUT, Praha 2;  Fyziologický ústav, 1. lékařská fakulta Univerzity Karlovy, Praha 3;  Radiodiagnostická klinika, Všeobecná fakultní nemocnice a 1. lékařská fakulta Univerzity Karlovy, Praha 4
Published in: Rozhl. Chir., 2019, roč. 98, č. 6, s. 233-238.
Category: Review


The development of a low-flow vascular prosthesis is a very topical issue. The authors present a pathway for the development of a prosthesis with optimal properties based on the idea of mimicking the characteristics of a biological model (saphenous vein graft) and programming these properties in the model of the prosthetic substitute. The vascular prosthesis presented consists of three layers – a non-absorbable scaffold representing vascular “media”, and two absorbable collagen layers – pseudointima and pseudoadventitia. The basic methods of physical testing are presented – the single axis stretch test and inflation-extension test, as well as other procedures that affect the final properties. These include collagen curing, antithrombotic treatment of the inner layer and the use of sterilization methods. The designed new graft was successfully implanted in an ovine model.


vascular substitutes for low-flow peripheral bypass grafting – testing

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