Thrombolytic Therapy of Acute Peripheral Arterial Occlusions of Limb Arteries

Authors: J. Buček;  R. Staffa;  B. Vojtíšek *
Authors‘ workplace: II. chirurgická klinika FN u sv. Anny v Brně a LF Masarykovy Univerzity, Brno, přednosta: prof. MUDr. Robert Staffa, Ph. D. ;  KZM FN u sv. Anny v Brně a LF Masarykovy Univerzity, Brno, přednosta: MUDr. Jiří Vaníček, Ph. D. *
Published in: Rozhl. Chir., 2011, roč. 90, č. 9, s. 512-516.
Category: Monothematic special - Original


Thrombolytic therapy is a method of solution of thrombotic arterial occlusions of limbs using the physiological process of fibrinolysis. The severity of limb ischemia is the crucial for therapy. If immediate recanalization of arterial system is necessary than primarily surgical teratment is chosen.

The Method:
The arterial closures in infrainguinal localization are indicated for thrombolysis. Especially occlusions of crural vessels and the closures of previous vascular reconstruction (bypass) are indicated. The methods of local intra-arterial thrombolysis with application of recombinant tissue plasminogen activator, (rt-PA Actilyse) through catheter introduced into the level of thrombotic occlusion by Seldinger’s Metod are used in our department.

The authors present retrospectively analyzed set of 51 patients (12 women and 39 men aged 33 to 85 years) with acute arterial occlusion solved with thrombolytic therapy in the period 02/2007 – 03/2010. Complete recanalization was achieved in 43 cases (patients) (84%), high amputation of limbs was performed in 3 cases (5.9%).

Key words:
thrombolysis – rt-PA – acute thrombosis – acute limb ischemia 


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Surgery Orthopaedics Trauma surgery
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