Castleman’s Disease – Mimicking a Malignant Lymphoma


Authors: Š. Zavázalová 1;  P. Jirák 2;  M. Syrůček 3;  D. Kovář 1;  J. Astl 1
Authors‘ workplace: ORL klinika 3. LF UK a ÚVN Praha, přednosta prof. MUDr. J. Astl, CSc. 1;  Oddělení ORL a chirurgie hlavy a krku Nemocnice Na Homolce, Praha, primář oddělení MUDr. P. Jirák 2;  Oddělení patologie Nemocnice Na Homolce, primář oddělení MUDr. M. Syrůček 3
Published in: Otorinolaryng. a Foniat. /Prague/, 63, 2014, No. 4, pp. 246-250.
Category: Case History

Overview

Castleman’s disease is a rare polyclonal lymphoproliferative disease, which becomes manifest as a benign hyperplasia of lymphatic nodes in various localizations and possibly by systemic symptoms. Histopathology provides division into three groups – hyaline-vascular (most frequent), plasma cellular, and mixed. The clinical manifestation provides a division into unicentric (localized) and multicentric (generalized) form. These variants differ by a clinical course, efficient therapy and prognosis. Histopathological examination is the method of choice in the diagnosis of Castleman’s disease. There has been no standardized therapy so far. It may be certified, though, that a complete surgical removal of the lymph nodes provides a curative method in the unicentric form. In the multicentric form the systemic therapy is necessary as well. In our report the case of a 35 years old man with gradually progressing cervical lymphadenopathy is described.

Keywords:
Castleman’s disease, lymphadenopathy, lymph nodes, histopathologic examination


Sources

1. Kawabata, H., Kadowaki, N., Nishikori, M., Kitawaki, T.,Kondo, T., Ishikawa, T., Yoshifuji, H., Yamakawa, N., Imu-ra, Y., Mimori, T., Matsumura, Y., Miyachi, Y., Matsuba-ra, T., Yanagita, M., Haga, H., Takaori-Kondo, A.: Clinical features and treatment of multicentric Castleman‘s disease: a retrospective study of 21 Japanese patients at a single institute. J. Clin. Exp. Hematop., 53, 2013, 1, s. 69-77.

2. Majerčáková, D.: Castlemanova choroba. Vnitř. Lék., 58, 2012, 3, s. 216-220.

3. ManmeetKaur Gill, VijaySuri, Vijay K. Dubey, Manisha-Makkar: Cytological diagnosis of Castleman‘s disease of the soft tissue. J. Cytol., 2013, 3, s. 213-215.

4. Mrzena, L.: Diferenciální diagnostika patologických útvarů na krku. Postgraduální medicína, s. 1024-1028.

5. Muzes, G., Sipos, F., Csomor, J., Sréter, L.: Multicentric Castleman’s disease: a challenging diagnosis. Pathol. Oncol. Res., 19, 2013, 3, s. 345-351. doi: 10.1007/s12253-013-9619-z. Epub 2013 Mar 21.

6. Szturz, P., Moulis, M., Adam, Z., Šlaisová, R., Koukalová, R., Řehák, Z., Volfová, P., Hájek, R., Mayer, J.: Castlemanova choroba. Klin. Okol., 24, 2011, 6, s. 424-434.

7. Szturz, P., Plank, L., Kristek, J., Rehak, Z., Koukalova, R., Pipal, R., Tesar, J., Cermakova, Z., Gottwaldova, J., Vanicek, J.,Slaisova, R., Skorpik, M., Adam, Z., Smardova, L., Mayer: Castlemanova choroba v obrazech. Postgraduální medicína 01/2014.

Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account