Ganglioneuroma withMalignant Transformation

Authors: L. Školoudík;  M. Rešl *;  J. Vokurka;  J. Růžička;  P. Čelakovský;  E. Šimáková *
Authors‘ workplace: Klinika ušní, nosní, krční LF UK a FN, Hradec Králové, přednosta doc. MUDr. J. Vokurka, CSc. Fingerlandův ústav patologie LF UK a FN, Hradec Králové, přednosta prof. MUDr. I. Šteiner, CSc. *
Published in: Otorinolaryng. a Foniat. /Prague/, , 2003, No. 2, pp. 92-95.


The authors present two cases of parapharyngeal ganglioneuromas. This, as a rulewell differentiated benign neuroectodermal tumour, is usually in the posterior mediastinum and ina retroperitoneal position. It is very rarely found in the parapharyngeal space. The first caseinvolved a ganglioneuroma in a two-year-old girl with a typical histological picture. The secondpatient was a 58-year-old woman where histological examination of the tumor proved signs ofmalignization and the affection was consistent with a malignant schwannoma which developed inthe ganglioneuroma. We assume that a manifestation of malignization in a de novo formed ganglioneuromawas involved and not secondary maturing of a ganglioneuroma from a neuroblastoma.

Key words:
parapharyngeal space, ganglioneuroma, malignant schwannoma, neuroblastoma.

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Audiology Paediatric ENT ENT (Otorhinolaryngology)
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