Contribution to the Elucidation of theEtiology of Méniére’s Disease

Authors: J. Rosocha;  J. Kovaľ;  M. Šuchaň;  A. Elbertová;  S. Krempaská
Authors‘ workplace: Združená tkanivová banka, Lekárska fakulta UPJŠ a FNsP, Košice, prednosta MVDr. J. Rosocha, CSc. Klinika ORL a foniatrie, Lekárska fakulta UPJŠ a FNsP, Košice, prednosta doc. MUDr. J. Kovaľ, CSc. Laboratórna časť oddelenia klinickej imunológie a alergológ
Published in: Otorinolaryng. a Foniat. /Prague/, , 2001, No. 3, pp. 172-177.


The authors submit a complex of immunological and immunochemical examinationsof patients with the working diagnosis of Méniére’s disease and progressive sensorineural hearingdisorder. All tests were made on the basis of solubilized antigens of the human cochlea. Isolatedproteins were characterized by SDS PAGE. For assessment of the immunological basis of the diseasethe authors used the following tests: immunoblotting, ELISA, CD69 analysis of peripheral CD3+lymphocytes by flow cytometry after stimulation with cochlear antigens and the lymphocytetransformation test. The tests revealed the irregular formation of autoantibodies and irregularactivation of periipheral circulating CD3+ lymphocytes in patients. This can be partially consideredthe result of local damage of the cochlea or expression of pathological surface structures andavailability of normally not present local antigens as a result of various stimuli (viral damage,pressure of endolymph etc.). Based on these results the view can be supported that Méniér e’s diseaseis from the etiological aspect beyond doubt an autoimmune disease. It is however possible that asa result of the induction of the however possible that as a results of the induction of the autoimmuneprocess the manifestations of the disease have a progressive trend.

Key words:
cochleovestibular disorder, Méniére’s disease, progressive sensorineural hearingdisorder, immunology.

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Audiology Paediatric ENT ENT (Otorhinolaryngology)

Article was published in

Otorhinolaryngology and Phoniatrics

2001 Issue 3

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account