Marker Ki-67 and Prognosisof Carcinoma of the Pharynx and Upper Larynx - Preliminary Results

Authors: P. Smilek;  K. Hušek;  R. Kostřica;  J. Rottenberg;  J. Žaloudík;  P. Dušek
Authors‘ workplace: ORL klinika FN u sv. Anny, Brno, přednosta prof. MUDr. R. Kostřica, CSc. I. patologicko-anatomický ústav FN u sv. Anny, Brno, přednosta prof. MUDr. J. Buček, CSc. Univerzitní onkologické centrum, Brno, programový vedoucí doc. MUDr. J. Žaloudík, CSc.
Published in: Otorinolaryng. a Foniat. /Prague/, , 2000, No. 2, pp. 110-113.


Prognostic factors used in head and neck tumours in clinical practice such as age,sex, general condition and immunological status have only a low prognostic value. Also histopathological grading, primary site and assessment of the TNM stage are very subjective. Quantitativeassessment of the basic characteristics of the tumour may permit to predict its behaviour moreaccurately. Therefore the authors assessed in 42 patients with carcinoma of the pharynx and theupper portion of the larynx, treated at our Clinic and then followed-up for 4-9 years, in addition tosite, TNM classification and histopathological grading also marker Ki-67. These factors wererelated by one-dimensional statistical analysis to the total period of survival and survival withoutsymptoms of the disease. Statistical significance was not proved but the character of the survivalcurve indicates possible successful predictions of the development in patients with head and neckcancer. There is also a statistically significant high incidence of well differentiated tumours in patientsin the IVth TNM stage. It is probable that after addition of further cytokinetic indicators it will bepossible to find by multidimensional analysis suitable prognostic factors in head and neck tumours.

Key words:
prognosis of head and neck cancer, marker Ki-67.

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Audiology Paediatric ENT ENT (Otorhinolaryngology)
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