Paediatric clinical pharmacist: a potential benefit?

Czech version

Authors: Petra Rozsívalová ^1,2
Authors‘ workplace: Oddělení klinické farmacie, Nemocniční lékárna FN Hradec Králové ¹; Katedra sociální a klinické farmacie FaF UK, Hradec Králové ²
Published in: Čas. Lék. čes. 2019; 158: 276-278
Category: Review Article

Overview

Medication errors in paediatric prescribing occur in approximately 10–15 % cases, almost half of these errors are represented by incorrect drug dosing. Maturational changes in pharmacokinetics and/or pharmacodynamics parameters of paediatric patients across different paediatric categories represent a challenge to optimal drug prescribing. Especially neonatal and infant populations along with obese children of adult size are the most vulnerable groups prone to medication errors. Clinical pharmacist focused on paediatric pharmacotherapy verification is another element ensuring safe and rational medication use across different paediatric specialities.

Keywords:

paediatrics – clinical pharmacy – pharmacotherapy

Sources

Assiri GA, Shebl NA, Mahmoud MA et al. What is the epidemiology of medication errors, error-related adverse events and risk factors for errors in adults managed in community care contexts? A systematic review of the international literature. BMJ Open 2018; 8(5): e019101.
Ghaleb MA, Barber N, Franklin BD et al. Systematic review of medication errors in pediatric patients. Ann Pharmacother 2006; 40(10): 1766–1776.
Rishoej RM, Almarsdóttir AB, Christesen HT et al. Medication errors in pediatric inpatients: a study based on a national mandatory reporting system. Eur J Pediatr 2017; 176(12): 1697–1705.
van den Anker J, Reed MD, Allegaert K et al. Developmental changes in pharmacokinetics and pharmacodynamics. J Clin Pharmacol 2018; 58(Suppl. 10): S10–S25.
Neofax Drug Monographs. Acetaminophen. OFIRMEV intravenous injection, acetaminophen intravenous injection. Mallinckrodt Hospital Products Inc. (per FDA), Hazelwood, 2017.
Mitra S, Florez ID, Tamayo ME et al. Association of placebo, indomethacin, ibuprofen, and acetaminophen with closure of hemodynamically significant patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. JAMA 2018; 319(12): 1221–1238.
Kinderformularium: Paracetamol. Dostupné na: www.kinderformularium.nl/geneesmiddel/21/paracetamol
Lexicomp online. Paracetamol neonatal dosing.
McWilliam SJ, Antoine DJ, Smyth RL, Pirmohamed M. Aminoglycoside-induced nephrotoxicity in children. Pediatr Nephrol 2017; 32(11): 2015–2025.
Maaskant JM, Vermeulen H, Apampa B et al. Interventions for reducing medication errors in children in hospital. Cochrane Database Syst Rev 2015; 3: CD006208.
Department of Health. National Service Framework for Children, Young People and Maternity Services. London, 2004.

Labels

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management

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