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Intrapleural alteplase therapy: what are the knowns and unknowns?


Authors: Judita Staša 1;  Jana Gregorová 1,2;  Norbert Pauk 3
Authors‘ workplace: Oddělení klinické farmacie, Nemocnice Na Bulovce, Praha 1;  Ústav aplikované farmacie, Farmaceutická fakulta VFU Brno 2;  Klinika pneumologie 3. LF UK a Nemocnice Na Bulovce, Praha 3
Published in: Čas. Lék. čes. 2019; 158: 295-299
Category: Review Article

Overview

In pneumology, enzymatic properties of plasmin are used to disrupt fibrin adhesions and septations formed during pathological conditions of the pleural cavity. In that case, fibrinolytics are administrated locally via a chest tube in the pleural cavity to evacuate pathological effusion. Although the first intrapleural administration of fibrinolytic occurred seventy years ago, there has been no consensus on dosing or a uniform procedure of their application. The aim of the article is to summarize current knowledge of alteplase usage in pneumology and discuss practical aspects of its intrapleural application regarding specific possibilities in the Czech Republic.

Keywords:

intrapleural fibrinolytics – alteplase – pleural infection – fibrinolytic therapy


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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management

Article was published in

Journal of Czech Physicians

Issue 7-8

2019 Issue 7-8

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