Smoking and pharmacological interactions
Authors:
František Perlík
Authors‘ workplace:
Farmakologický ústav 1. LF UK a VFN v Praze
Published in:
Čas. Lék. čes. 2017; 156: 13-14
Category:
Review Article
Overview
Cigarette smoking can affect drug metabolism via pharmacokinetic and pharmacodynamic mechanisms, and a sudden change in smoking status can render patients at risk of serious adverse reactions, eg. after clozapine. Patients should be regularly monitored with regard to their smoking status and extent of cigarette consumption and doses of relevant medications adjusted accordingly.
Keywords:
drug interactions, smoking, pharmacokinetics, pharmacodynamics
Sources
1. Zewin S, Benowitz NL. Drug interactions with tobacco smoking: an update. Clin Pharmacokinet 1999; 36: 425−438.
2. Dobrinas M, Cornuz J, Oneda B et al. Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility. Clin Pharmacol Ther 2011; 90: 117−125.
3. Benowitz NL. Pharmacology of nicotine: addiction, smoking induced disease, and therapeutics. Annu Rev Pharmacol Toxicol 2009; 49: 57−71.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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