Galectins in Squamous Cell Carcinomas of the Head and Neck Cancers
Authors:
Z. Čada 1,2; J. Plzák 1,2,3; M. Chovanec 1,2,3; B. Dvořánková 1,3; L. Lacina 1,3,4; P. Szabó 1; K. Smetana, Jr. 1,3; J. Betka 2
Authors‘ workplace:
Karlova Univerzita, 1. lékařská fakulta, Anatomický ústav, Praha
1; Karlova Univerzita, 1. lékařská fakulta, Klinika otorinolaryngologie a chirurgie hlavy a krku FN Motol, Praha
2; Karlova Univerzita, 2. lékařská fakulta, Centrum buněčné terapie a tkáňových náhrad, Praha
3; Karlova Univerzita, 1. lékařská fakulta, Dermatovenerologická klinika VFN, Praha
4
Published in:
Čas. Lék. čes. 2008; 147: 559-563
Category:
Review Article
Overview
Cancers of head and neck represents about 5% of all tumors. 80 to 90% of these tumors are constituted of squamous cell carcinomas. Despite a rapid progress in diagnostics and therapy the overall 5-year survival of this type of cancer is among the lowest of the major cancer types. This unfavourable situation needs the extensive research to found new markers to better characterize biological behavior of tumors as a rational background for more sophisticated therapeutic modalities. Among the most promising markers are endogenous lectins called galectins and their ligands. Especially galectin-1, -3 and -7 play a key role in pathology of squamous cell carcinomas.
Key words:
squamous cell carcinomas, lectins, galectins, prognostic markers.
Sources
1. Myers, E. N., Suen, J. Y., Myers, J. N., Hanna, E. Y. N.: Cancer of the head and neck. Philadelphia, Pennsylvania, Saunders, 2003, s. 5–28.
2. Boring, C. C., Squires, T.S., Ton, T.: Cancer statistics, 1992. CA Cancer J. Clin., 1992, 42, s. 19–38.
3. Ogawa, T., Tsurusako, Y., Kimura, N. et al.: Comparison of tumor markers in patients with squamous cell carcinoma of the head and neck. Acta Otolaryngol (Stockh), 1999, 540 (Suppl.), s. 72–76.
4. Smetana, K., Jr., André, S.: Mammalian lectin as tool in glycochemistry and histochemistry with relevance for diagniostic procedure. In: McMahn, R. J. (Ed.) Avidin-Biotin Interactions, Methods and Applications. Humana Press, Totowa, NJ, USA, 2008, s. 171–185.
5. Kocourek, J., Hořejší, V.: Defining a lectin. Nature, 1981, 290, s. 188.
6. Gabius, H.-J.: Animal lectins. Eur J Biochem., 1997, 243, s. 543–576.
7. Plzák, J., Smetana, K. Jr., Hrdličková, E. et al.: Expression of galectin-3-reactive glycoligands in squamous cell cancer and normal epithelial cells as a marker of differentiation. Int. J. Oncol., 2001, 19, s. 59–64.
8. Lohr M., Lensch M., Andre S. et al.: Murine Homodimeric Adhesion/Growth-Regulatory Galectins-1, -2 and -7: Comparative Profiling of Gene/Promoter Sequences by Database Mining, of Expression by RT-PCR/Immunohistochemistry and of Contact Sites for Carbohydrate Ligands by Computational Chemistry. Folia Biologica, 2007, 53, s. 109–128.
9. Cooper, D. N. W., Massa, S. M., Barondes, S. H.: Endogenous muscle lectin inhibit myoblast adhesion to laminin. J. Cell Biol., 1991, 115, s. 1437–1448.
10. Perillo, N. L., Uittenbogaart, C. H., Nguyen, J. T. et al.: Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J. Exp. Med., 1997, 185, s. 1851–1858.
11. Sanford, G. L., Harris-Hooker, S.: Stimulation of vascular cell proliferation by ß-galactoside-binding lectins. FASEB J., 1990, 4, s. 2912–2918.
12. Adams, L., Scott, G.K., Weinberg, C.: Biphasic modulation of cell growth by recombinant human galectin-1. Biochem. Biophys. Acta, 1996, 1312, s. 137–144.
13. Vyakarman, A., Daggher, S. F., Wang, J. L. et al.: Evidence for a role for galectin-1 in pre-mRNA splicing. Mol. Cell Biol., 1997, 17, s. 4730–4737.
14. Plzák, J., Smetana, K. Jr., Chovanec, M., Betka, J.: Glycobiology of head and neck squamous epithelia and carcinomas. ORL, 2005, 67, s. 61–69.
15. Motlík, J., Klíma, J., Dvořánková, B., Smetana, K. Jr.: Porcine epidermal stem cells as a biomedical model for wound healing and normal/malignant epithelial cell propagation. Theriogenology, 2007, 67, s. 105–111.
16. Čada, Z., Bouček, J., Dvořánková, B. et al.: Nucleostemin expression in squamous cell carcinoma of the head and neck. Anticancer research, 2007, 27, s. 3279–3284.
17. Smetana, K. Jr., Holíková, Z., Klubal, R. et al.: Coexpression of binding sites for A(B) histo-blood group trisaccharides with galectin-3 and Lag antigen in human Langerhans cells. J. Leukocyte Biol., 1999, 66, s. 644–649.
18. Polyak, K., Xia, Y., Zweier, J. L. et al.: A model for p53-induced apoptosis. Nature, 1997, 389, s. 300–305.
19. Honjo, Y., Inohara, H., Akahani, S. et al.: Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clin. Cancer Res., 2000, 6, s. 4635–4640.
20. Piantelli, M., Iacobelli, S., Almadori, G. et al.: Lack of expression of galectin-3 is associated with a poor outcome in node-negative patients with laryngeal squamous-cell carcinoma. J. Clin. Oncol., 2002, 20, s. 3850–3856,
21. Plzák, J., Betka, J., Smetana, K. Jr. et al.: Galectin-3 – an emerging prognostic indicator in advanced head and neck carcinoma, European. Journal of Cancer, 2004, 40, s. 2324–2330.
22. Magnaldo, T., Fowlis, D., Darmon, M.: Galectin-7, a marker of all types of stratified epithelia. Differentiation, 1998, 63, s. 159–168.
23. Chovanec M., Smetana K. Jr., Plzák J. et al.: Detection of new diagnostic markers in pathology by focus on growth-regulatory endogenous lectins. The case study of galectin-7 in squamous epithelia. Prague Med. Rep., 2005, 106, s. 209–216.
24. Bernerd, F., Sarasin, A., Magnoldo, T.: Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. Cell Biology, 1999, 96, s. 11329–11334.
25. Saussez, S., Cucu, D. R., Decaestecker, C. et al.: Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer. Ann. Surg. Oncol., 2006, 13, s. 999–1009.
26. Čada, Z., Chovanec, M., Smetana, K., Jr. et al.: Growth/malignancy-regulatory galectin-7: will the lectinęs activity in vitro establish clinical correlations in head and neck squamous cell and basal cell carcinomas? Histol. Histopathol., 2008 (in press).
27. Liu, M., Weynand, B., Delos, M.: Prognostic factors in squamous cell carcinomas of the head and neck. Acta Oto-rhino-laryngol Belg., 1999, 53, s. 155–160.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
Most read in this issue
- Galectins in Squamous Cell Carcinomas of the Head and Neck Cancers
- Rationality and Irrationality in the Medicine and in the Life
- Hiatal hernia and Barrett’s oesophagus Impact on symptoms occurrence and complications
- Primary B-cell pituitary lymphoma of the Burkitt type: case report of the rare clinic entity with typical clinical presentation