Hereditary Predisposition for Development of Breast and OvarianCarcinoma

Authors: M. Zikán;  N. Jančárková 1;  P. Pohlreich;  B. Matouš;  Z. Kleibl;  J. Stříbrná;  J. Živný 1
Authors‘ workplace: Ústav biochemie a experimentální onkologie 1. LF UK, Praha 1Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2004; : 26-30


Part of breast and ovarian cancer cases develops on the hereditary predisposition, i.e. mutation in one of predisposinggenes. Although this proportion is relatively small, 5–10%of all breast and ovarian carcinomas, it represents a groupwith clearly defined etiologic factor. Predictive analysis of unaffected family members allows to identify individualsat high risk of cancer and to include them into the programme of primary and secondary cancer prevention. Followingarticle presents basic review of the hereditary predisposition to breast and ovarian cancer focusing especially onBRCA1 and BRCA2 genes, which are responsible for almost three-quarters of those hereditary tumours.

Key words:
breast cancer, ovarian cancer, BRCA1, BRCA2.

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