The Antiphospholipid Syndrome and Antiphospholipid Antibodies

Authors: K. Malíčková;  T. Fučíková
Authors‘ workplace: Ústav klinické imunologie a alergologie 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2001; : 465-468


Antiphospholipid syndrome is a rate systemic autoimmune disease characterized by widespread arterial and venousthrombosis, recurrent abortion and thrombocytopenia. Laboratory tests reveal antibodies against phospholipids.These antibodies are detected by functional tests for the lupus anticoagulant, the anticardiolipin ELISA, theanti-b2-glycoprotein 1 ELISA and ELISA tests for antibodies against other cofactors and phospholipids. Pathogeneticmechanisms of thrombosis are poorly understood. Diagnostic assays for detection of antiphospholipid have not beenyet adequately standardized.

Key words:
antiphospholipid syndrome, antiphospholipid antibodies, lupus anticoagulant, laboratory detection.

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