DNA Methylation and Neoplasia
Authors:
J. Mareš; Z. Sedláček; P. Goetz
Authors‘ workplace:
Ústav biologie a lékařské genetiky 2. LF UK, Praha
Published in:
Čas. Lék. čes. 2000; : 291-294
Category:
Overview
DNA methylation and acetylation of histone proteins represent two global mechanisms controlling the geneexpression. DNA methylation profiles alter during the development of the organism and during progression ofneoplasia. Three types of alterations of the DNA methylation profiles were observed in the tumor cells: hypo-methylation, hypermethylation and the loss of imprinting. Beside the intra-gene mutation and the heterozygosityabsence, DNA methylation can be understood as the third mechanism of tumor-suppressor gene inactivation in thegenesis of neoplasia. Our review article brings recent findings and hypotheses on the role of DNA methylation inthe carcinogenesis and its possible application in the diagnostics and therapy of the malignant proliferation.
Key words:
DNA methylation, CpG islands, tumor-suppressor genes, modulation of gene expression, carcinoge-
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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