Effects of Normalised Levels of Previously Increased TSHon Patient’s Neuro-Psychologic Profile

Overview

Background.
Isolated TSH increase - „subclinical hypothyreosis“ (SH) appears to be comparatively common. Itsincidence among women over sixty has been estimated up to 17 %. Though SH was assumed to be entirelyasymptomatic, recent findings revealed various fine subjective and objective symptoms of the disease.Methods and Results. Twenty otherwise healthy female patients with SH diagnosis were examined. Usingpersonality questionnaire MMPI/100 eight different clinical scales and two control scales were evaluated, usingWechsler’s memory scale WM-R 5 memory quotients were tested. The group was randomised i nto a subgroup treatedfor six month with placebo and a subgroup where thyroxin was administrated and thyroidal test normalised.Psychological testing repeated before and after the treatment, results evaluated using paired t-test. Results indicatethat: 1. Patients with SH did not differ in personality features, they only had a higher tendency to the depressivemood, which could be positively influenced by thyroxin (significance at 5 % level). 2. Thyroxin treatment broughtabout improvement of some cognitive parameters of the verbal (p

Key words:
subclinical hypothyreosis, neuro-psychological investigation, thyroxin treatment.