Authors: V. Chábová; V. Tesař; J. Perušičová 1; T. Zima 2; J. Žabka; I. Rychlík; M. Merta; V. Bradová; S. Štípek 2 Authors‘ workplace: I. interní klinika 1. LF UK a VFN, Praha, 1 Fakultní poliklinika I. LF UK, interní odd., Praha 2 Ústav lékařské chemie a biochemie I. LF UK, Praha Published in: Čas. Lék. čes. 1999; : 465-468 Category:
Background. Leptin is a new hormone influencing food intake, energy expenditure and body weight. This proteinis produced by adipocytes, exerts its effects on brain, endocrine pancreas and other organs by activating transmem-brane receptors and is cleared from plasma mainly by the kidneys. The aim of our study was to compare plasmaconcentrations of leptin in our nephrological out-patients and controls.Methods and Results. We examined 36 diabetic patients with various stages of nephropathy, 12 males withnephrotic syndrome due to membranous nephropathy, 15 dialysis patients and 11 controls. Leptin was assessed inplasma by ELISA.There was a significant difference between plasma levels of leptin in males and females (7.7 ± 11.4 vs 17.6 ± 17.3,p
Key words: plasma leptin concentrations, renal disease.
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