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proLékaře.cz / Journals / Internal Medicine / 2023 - 5

Internal comorbidities and complications of multiple sclerosis therapy – don’t be caught off guard!

Czech version

Authors: Dominika Šťastná 1;  Jana Seňavová 2,3;  Michaela Andělová 1;  Ingrid Menkyová 1,4;  Otakar Pšenička 5;  Dana Horáková 1
Authors‘ workplace: Neurologická klinika a Centrum klinických neurověd 1. LF UK a VFN v Praze 1;  I. interní klinika – klinika hematologie 1. LF UK a VFN v Praze 2;  BIOCEV, 1. LF UK v Praze 3;  II. neurologická klinika LF UK a UNB, Bratislava 4;  III. interní klinika – endokrinologie a metabolismu 1. LF UK a VFN v Praze 5
Published in: Vnitř Lék 2023; 69(5): 294-298
Category:
doi: https://doi.org/10.36290/vnl.2023.058

Overview

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, mainly affecting young adults. Factors positively influencing its course include early antiinflammatory treatment and the influencing of other comorbidities. The most common comorbidities occurring in MS patients with a higher frequency than in the general population are neurological, psychiatric, cardiovascular, metabolic and autoimmune. Just as comorbidity compensation affects the course of MS, in some cases, MS decompensation is associated with a worse course of associated diseases. Due to common risk factors and partially shared immunopathogenesis, treatment covering multiple conditions can be used, especially for some autoimmune diseases. On the other hand, some drugs may potentiate the development of other autoimmunity or disorder. A special topic is the side effects and complications of treatment (especially infections and malignancies) of disease-modifying therapies used in patients with MS. However, the potential treatment discontinuation carries significant risks and should always be discussed with the MS specialist. Therefore, close interdisciplinary collaboration is crucial.

Keywords:

autoimmune diseases – Drug interactions – comorbidities – adverse effects – disease -modifying therapies – multiple sclerosis

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Zemřela prof. MUDr. Marie Brodanová, DrSc.
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Internal Medicine

Issue 5
2023 Issue 5
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