Obstructive sleep apnea and hypertension: the role of gut microbiome
Authors:
Pavel Šiarnik 1; Katarína Klobučníková 1; Imrich Mucska 2; Alžbeta Hlucháňová 3; Oto Hanus 4; Peter Turčáni 1; Branislav Kollár 1
Authors‘ workplace:
I. neurologická klinika Lekárskej fakulty Univerzity Komenského a Univerzitnej nemocnice Bratislava
1; Ambulancia pre spánkové poruchy dýchania, Univerzitná nemocnica Bratislava
2; Neurologické oddelenie, Nemocnica sv. Cyrila a Metoda, Univerzitná nemocnica Bratislava
3; Neurologická klinika, Ústredná vojenská nemocnica SNP Ružomberok
4
Published in:
Vnitř Lék 2020; 66(7): 415-419
Category:
Overview
Obstructive sleep apnea is common disorder affecting approximately one quarter of the common population. Prevalence is even higher in a population with increased vascular risk. Obstructive sleep apnea is a significant risk factor for hypertension, with approximately 50% of obstructive sleep apnea patients suffering hypertension. While the relationship between sleep apnea and hypertension has been firmly established, mechanisms linking these disorders are still poorly understood. Importance of sympathetic nervous system and renin-angiotensin-aldosterone system hyperactivity as well as endothelial dysfunction is suspected. There is increasing evidence supporting gut dysbiosis as one of the underlying mechanisms. Current article describes possible mechanisms linking obstructive sleep apnea with the development of hypertension. The role of gut microbiota in this process is discussed more closely.
Keywords:
gut microbiome – hypertension – obstructive sleep apnea
Sources
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2020 Issue 7
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