Application of stem cells in orthopedics

Authors: Pavel Žák
Authors‘ workplace: IV. interní hematologická klinika LF UK a FN Hradec Králové, přednosta doc. MUDr. Pavel Žák, Ph. D.
Published in: Vnitř Lék 2015; 61(6): 597-598

Předneseno na mezioborovém sympoziu s postgraduálním zaměřením „Diabetik – společný pacient diabetologa a ortopeda“ 10. října 2014 v Hradci Králové.


Regeneration of articular cartilage remains a major challenge in orthopaedics. Cell-based therapies (with chondrocyte and MSCs – mesenchymal stem cells) to augment cartilage repair have received considerable interest during recent years. Adipose MSCs have been used in the Czech Republic for osteoarthritis therapy, despite not being re­commended by the Czech Orthopaedic Association. This lecture reviews the studies and their level of evidence for orthopaedic routine therapy of osteoarthritis.

Key words:
mesenchymal stem cells – osteoarthritis


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2. Centeno CJ, Busse D, Kisiday J et al. Increased knee cartilage volume in degenerative joint disease usány percutaneously implanted autologous mesenchymal stem cells. Pain Physician 2008; 11(3): 343–353.

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4. Vangsness CT, Farr J, Boyd J et al. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial menisectomy. J Bone Point Surg Am 2014; 96(2): 90–98.

5. Peeters CM, Leijs MJ, Reijman M et al. Safety of intra-articular cell-therapy with culture -expanded stem cells in humans: A systematic literature review. Osteoarthritis Cartilage 2013; 21(10): 1465–1473.

Diabetology Endocrinology Internal medicine

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Internal Medicine

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