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The role of uric acid and allopurinol therapy in cardiovascular disease


Authors: Aleš Linhart;  Daniel Rob
Authors‘ workplace: II. interní klinika kardiologie a angiologie 1. LF UK a VFN Praha, přednosta prof. MUDr. Aleš Linhart, DrSc., FESC, FCMA
Published in: Vnitř Lék 2015; 61(5): 421-430
Category: Reviews

Overview

Uric acid elevation is very common among patients with cardiovascular, renal and metabolic diseases. The role of uric acid in the pathogenesis of these diseases has been subject of intensive research and scientific discussions for decades. Allopurinol, which has been used in clinical practice for almost 50 years, is the drug of first choice for long-term control of gout. Due to its efficiency, low price and well-known risk profile, it is a widely prescribed drug. However allopurinol treatment in patients with asymptomatic hyperuricemia and cardiovascular diseases is still controversial. This review summarizes the increasing evidence of experimental and clinical studies suggesting that uric acid may play a causal role in cardiovascular disorders pathogenesis. The current evidence suggests that allopurinol therapy could provide a clinical benefit in the prevention and treatment in many of these conditions.

Key words:
allopurinol – cardiovascular diseases – gout – hyperuricemia – uric acid – xantin-oxidase inhibition


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Diabetology Endocrinology Internal medicine

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Internal Medicine

Issue 5

2015 Issue 5

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