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Thrombohaemorrhagic syndrome in patients with a myeloproliferative disease with thrombocythemia


Authors: M. Penka 1;  J. Kissová 1;  A. Buliková 1;  J. Zavřelová 1;  J. Ovesná 1;  T. Pavlík 2
Authors‘ workplace: Oddělení klinické hematologie FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Miroslav Penka, CSc. 1;  Institut biostatistiky a analýz Lékařské a Přírodovědecké fakulty MU Brno, vedoucí pracoviště doc. RNDr. Ladislav Dušek, Ph. D. 2
Published in: Vnitř Lék 2011; 57(3): 306-311
Category: 60th birthday of prof. Mudr. Jiřího Vítovce, CSc, FESC

Overview

Thrombohaemorrhagic syndrome is a clinical syndrome manifesting with concurrent bleeding and thrombosis. It is associated with a range of pathological states, typically with myeloproliferative diseases, paraproteinaemia, liver disease as well as disseminated intravascular coagulation and similar syndromes (so called DIC-like syndrome). Thrombohaemorrhagic syndrome might be a symptom of chronic myeloproliferations, particularly if these are associated with thrombocythemia. It is most frequently linked to essential thrombocythemia. However, in this disease, it seems that the clinical symptoms of bleeding and thrombosis might not be directly determined by the number of platelets, as it would suggest itself, but that this can be consequent to other changes. These may include predisposition to thrombophilia, cardiovascular risk, leukocytosis etc. as well as, for example, platelet dysfunction. The present study focuses on platelet dysfunction in conjunction with clinical symptoms of bleeding and thrombosis.

Key words:
thrombohaemorrhagic syndrome – thrombosis – bleeding – myeloproliferation – thrombocythemia


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Labels
Diabetology Endocrinology Internal medicine
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