Geriatric syndromes and frailty syndrome – the Holy Grail of geriatric medicine

Authors: P. Weber;  P. Ambrošová;  D. Weberová;  K. Bielaková
Authors‘ workplace: Klinika interní, geriatrie a praktického lékařství Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednostka prof. MUDr. Hana Matějovská Kubešová, CSc.
Category: Online


The paper provides a practice-oriented overview of the main issues in geriatric medicine, including demographic analyses, description of the frailty syndrome and an emphasis on geriatric syndromes. Considering the trend towards aging population and its demographic prognosis, it is vital that all physicians (especially in the field of internal medicine) assume the basic knowledge of geriatric medicine and understand polymorbidity, frailty and geriatric syndromes, including their interrelationships and functional associations. A comprehensive treatment of any disease in advanced age (including geriatric syndromes and frailty) should be aimed at a causing disorder as well as it should improve and maintain self-sufficiency and retain intellectual functions and functional social relationships within the family and community.

Key words:
older age – demography – geriatric assessment (CGA) – frailty – geriatric syndromes


1. Blackburn JA, Dulmus CN (eds). Handbook of gerontology: evidence-based approaches to theory, practice, and policy. New York: Hoboken, N. J. Wiley 2007.

2. Ratnaike RN (ed.). Practical Guide to Geriatric Medicine. New York: Mc Graw Hill Comp., Inc. 2002.

3. Kalvach Z, Zadák Z, Jirák R et al. Geriatrie a gerontologie. Praha: Grada Publishing a.s., 2004.

4. Bongard FS, Sue DY (eds). Current Critical Care Diagnosis & Treatment. 2nd Ed. New York: Lange Medical Books/McGraw-Hill Medical Publishing Division 2003.

5. Weber P. Geriatrie jako interdisciplinární vědní obor na prahu 21. století. Vnitř Lék 2005; 51: 198–205.

6. Harari D, Martin FC, Buttery A et al. The older persons’ assessment and liaison team ‘OPAL’: evaluation of comprehensive geria­tric assessment in acute medical inpatients. Age Ageing 2007; 36: 670–675.

7. Stuck AE, Aronow HU, Steiner A et al. A trial of annual in-home comprehensive geriatric assessments for elderly people living in the community. N Engl J Med 1995; 333: 1184–1189.

8. Pathy MSJ, Sinclair AJ, Morley JE (eds). Principles and practice of geriatric medicine. 4th ed. Chichester: Wiley 2004.

9. Holmerová I, Jurasková B, Kalvach Z et al. Dignity and palliative care in dementia. J Nutr Health Aging 2007; 11: 489–494.

10. Nemeth F, Koval S, Zavazalova H et al. End of life. Bratisl Lek Listy 2007; 108: 239–245.

11. Matějovská Kubešová H et al. Akutní stavy v geriatrii. Praha: Galén 2009.

12. Moody HR. Aging: concepts and controversies. 6th Ed. London: Pine 2009.

13. Fauci AS, Braunwald E, Kasper DL et al. Harrison’s Principles of Internal Medicine. 17th Ed. New York: McGraw-Hill Medical Publishing Division 2008.

14. Scherl H. Increasing life expectancy – the big social issue of the 21st century? Z Gerontol Geriat 2003; 36: 95–103.

15. Zdravotnická ročenka České republiky. Praha: ÚZIS ČR 2009.

16. Alušík Š. Geriatrizace vnitřního lékařství. Vnitř Lék 2000; 46: 167–188.

17. Williams ME. Geriatric physical diagnosis: a guide to observation and asses­sment. Jefferson, N.C.: McFarland & Co. Inc. 2008.

18. Fried LP, Borhani NO, Enright P et al. The Cardiovascular Health Study: design and rationale. Ann Epidemiol 1991; 1: 263–276.

19. Topinková E. Geriatrie pro praxi. Praha: Galén 2005.

20. Leng SX, Xue QL, Tian J et al. Inflammation and frailty in older women. J Am Geriatr Soc 2007; 55: 864–871.

21. Yaffe K, Haan M, Blackwell T et al. Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc 2007; 55: 758–762.

22. Soriano RP, Fernandez HM, Cassel CK et al. Fundamentals of geriatric medicine: a case-based approach. New York: Springer 2007.

23. Applegate WB, Blass JP, Williams TF. Instruments for the functional assessment of older patients. N Engl J Med 1990; 322: 1207–1214.

24. Gupta A. Measurement scales used in elderly care. Oxford: Radcliffe Publishing 2008.

25. Gurcharan RS, Mulley GP (eds). Elderly medicine: a training guide. 2nd Ed. Edinburgh: Churchill Livingstone Elsevier 2007.

26. Tinetti ME, Williams CS, Gill TM. Dizziness among older adults: a possible geriatric syndrome. Ann Intern Med 2000; 132: 337–344.

27. Masoro EJ, Austad SN (eds). Handbook of the biology of aging. 7th Ed. London: Elsevier Academic Press, Burlington, MA 2011.

28. Kriegsman DM, Penninx BW, van Eijk JT et al. Self-reports and general practi­tioner information on the presence of chronic diseases in community-dwelling elderly. A study on the accuracy of patients’ self-reports and on determinants of inaccuracy. J Clin Epidemiol 1996; 49: 1407–1417.

29. Gross R, Bentur N, Einayany A et al. The validity of self-reports on chronic disease: characteristics of underreporters and implications for the planning of services. Public Health Rev 1996; 24: 167–182.

30. Humes HD (ed.). Kelley’s Textbook of Internal Medicine. 4th Ed. Philadelphia Lippincott Williams & Wilkins 2002.

31. Hunter JA, Haslett C, Chilver AR et al (eds). Davidson’s Principle and Practice of Medicine. Edinburgh: Churchill Livingstone 2002.

32. Inouye SK, Studenski S, Tinetti ME et al. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007; 55: 780–791.

33. Hazzard WR. Scientific progress in geriatric syndromes: earning an „A“ on the 2007 report card on academic geriatrics. J Am Geriatr Soc 2007; 55: 794–796.

34. Kalvach Z, Zadák Z, Jirák R et al. Geriatrické syndromy a geriatrický pacient. Praha: Galén 2008.

35. Salvedt I, Ophdal Mo ES, Fayers P et al. Reduced Mortality in Treating Acutely Sick, Frail Older Patients in a Geriatric Evaluation and Management Unit, A Prospective Randomized Trial. J Am Geriatr Soc 2002; 50: 792–798.

36. Crome P, Lally F. Frailty: joining the giants. CMAJ 2011; 183: 889–890.

37. Fried LP, Hadley EC, Walston JD et al. From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ 2005; 31: pe24.

38. Walston J, Hadley EC, Ferrucci L et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006; 54: 991–1001.

39. Rockwood K, Hubbard R. Frailty and the geriatrician. Age Ageing 2004; 33: 429–430.

40. Woodhouse KW, O’Mahony MS. Frailty and ageing. Age Ageing 1997; 26 245–246.

41. Jurasková B, Zadák Z, Solichová D et al. Monitoring fagocytové aktivity a volných radikálů u Helicobacter pylori. Vnitř Lék 2000; 46: 677–680.

42. Cassel CK, Cohen HJ, Larson EB et al (eds). Geriatric medicine: an evidence-based approach. 4th Ed. New York: Springer 2003.

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