Coagulopathy and differentiation syndrome: the main complications of the initial treatment of acute promyelocytic leukemia
Authors:
Z. Kořístek 1; P. Žák 2
Authors‘ workplace:
Interní hematoonkologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jiří Vorlíček, CSc.
1; Oddělení klinické hematologie II. interní kliniky Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jaroslav Malý, CSc.
2
Published in:
Vnitř Lék 2008; 54(7-8): 745-750
Category:
Review
Overview
Two main causes of early mortality of acute promyelocytic leukemia (APL) are rewieved, unique type of coagulopathy typical for APL and differentiation syndrome sometimes complicating treatment of APL with all‑trans retinoic acid (ATRA) or arsenic trioxide (ATO). The information covers analysis of the patophysiologies of both conditions and also recommendations considering treatments and preventive measures.
Key words:
acute promyelocytic leukemia – differentiation syndrome – RAS – ATRA syndrome – ATO syndrome – coagulopathy – annexin II – hyperfibrinolysis
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2008 Issue 7-8
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