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Anticoagulant treatment in patients with atrial fibrillation and chronic kidney disease – a common problem in the elderly

Czech version

Authors: Veselý Jiří 1,2;  Pudil Radek 1,3
Authors‘ workplace: Lékařská fakulta Univerzity Hradec Králové, Hradec Králové 1;  Kardiologická ambulance EDUMED, Náchod 2;  1. interní kardioangiologická klinika FN Hradec Králové 3
Published in: Geriatrie a Gerontologie 2023, 12, č. 3: 127-134
Category: Review Article

Overview

Veselý J, Pudil R. Anticoagulant treatment in patients with atrial fibrillation and chronic kidney disease – a common problem in the elderly.


Atrial fibrillation and chronic kidney disease are strongly interacting diseases common in elderly. This combination significantly increases morbidity and mortality especially due to their impact on stroke risk. Novel (direct) oral anticoagulants (NOACs/DOACs) are generally recommended as first line therapy for stroke prevention in atrial fibrillation. There is also evidence of effectiveness in patients with mild or moderate reduction of renal function. However, the use of this treatment in patients with seriously reduced renal function is still controversial. This article provides an overview of current options and evidence guiding the clinical use of warfarin and NOACs in patients with atrial fibrillation and chronic kidney disease

Keywords:

novel oral anticoagulants – elderly patients – atrial fibrillation – chronic kidney disease – anticoagulation therapy – creatinine clerance

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Geriatrics and Gerontology

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2023 Issue 3
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