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Biological therapy in oncology (I)


Authors: P. Králíčková;  J. Krejsek;  I. Krčmová
Authors‘ workplace: ÚSTAV KLINICKÉ IMUNOLOGIE A ALERGOLOGIE ;  Fakultní nemocnice Hradec Králové
Published in: Prakt. Lék. 2011; 91(4): 189-192
Category: Reviews

Overview

The incidence of cancer increased substantially during the 20th century. Cancer is the second leading cause of mortality in developed countries. Partially effective therapeutic approaches and medicamentous treatments:

– irradiation,
– chemotherapy, and
– later biological therapy

were developed in the second half of the last century to help combat this cancer epidemic. We review the efficacy of biological therapy based on cell-mediated immunity (BCG vaccination, cancer vaccination, adoptive immunotherapy).

The aim of biological therapy is to optimally target the tumorigenesis process and to reverse it with minimal side effects.

Key words:
biological treatment, bacterial adjuvants, cancer vaccination, adoptive immunotherapy.


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