Authors: K. Trnavský Authors‘ workplace: Ředitel: MUDr. Zdeněk Hadra ; Vedoucí lékař: prof. MUDr. K. Trnavský, DrSc. ; Institut postgraduálního vzdělávání ve zdravotnictví, Praha ; Arthrocentrum Praha Published in: Prakt. Lék. 2009; 89(3): 134-135 Category: Of different specialties
Corticosteroids have their firm place in the pharmacotherapy of rheumatoid arthritis. They are administered in high doses for suppression of acute exacerbation of the disease. Low-dose (between 5–7.5 mg of prednisone daily) in the combination with disease modifying drugs (like methotrexate, sulfasalazine) is the most widely used form of corticosteroids administration in 30 % of patients. Corticosteroids in low-dose are able to decrease the radiographic progression of joint destruction. Low-dose of corticosteroids are generally well tolerated and no new osteoporotic fractures were found in the treated patients.
Key words: Rheumatoid arthritis, corticosteroids therapy.
1. Bošmanský, K., Trnavský,K. Retrospektívny pohlad na použiti medikamentóznej liečby v skupine 100 chorých na reumatoidnú artritídu. Čas. lék. čes. 121, 1982, s. 95-97.
2. Caplan, L., Wolfe, F., Russell, A.S., Michaud, K. Corticosteroid use in rheumatoid arthritis: prevalence, predictors, correlates and outcomes. J. Rheumatol. 34, 2007, p. 696-706.
3. Everdingen, A.A., Jacobs, J.W., Siewerts, D.T. et al. Low-dose prednisone therapy for patients with early active rheumatoid arthritis. Ann. Int. Med. 136, 2002, p. 1-12.
4. Harris, E.D. Jr. Prednisolone in early rheumatoid arthritis: an antiinvasive effect. Arthr. Rheum. 52, 2005, p. 3324-3325.
5. Kirwan, J.R. The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The arthritis and rheumatism council low-dose glucocorticoid study group. New Engl. J. Med. 333, 1995, p. 142-146.
6. Saag, K.G., Koehnke, R.N., Caldwell, J.R. et al. Low-dose long term corticosteroid therapy in rheumatoid arthritis: An analysis of serious adverse events. Amer. J. Med. 1994, 96, p. 115-123.
7. Svensson, B., Boonen, A., Albertson, K. et al. Low-dose prednisolone in addition to the initial disease modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial. Arthr. Rheum. 52, 2005, p. 3360-3370.
8. Trnavský, K. Poznámky k použití kortikoidů v terapii revmatoidní artritidy. Rheumatologia 13, 1994, s. 177-180.
9. Wassenberg, S., Rau, R., Steinfeld, P., Zeidler, H. Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicentre, double-blind, placebo controlled trial. Arthr. Rheum. 52, 2005, p. 3371-3380.
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