#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Corticosteroids as a treatment of rheumatoid arthritis


Authors: K. Trnavský
Authors‘ workplace: Ředitel: MUDr. Zdeněk Hadra ;  Vedoucí lékař: prof. MUDr. K. Trnavský, DrSc. ;  Institut postgraduálního vzdělávání ve zdravotnictví, Praha ;  Arthrocentrum Praha
Published in: Prakt. Lék. 2009; 89(3): 134-135
Category: Of different specialties

Overview

Corticosteroids have their firm place in the pharmacotherapy of rheumatoid arthritis. They are administered in high doses for suppression of acute exacerbation of the disease. Low-dose (between 5–7.5 mg of prednisone daily) in the combination with disease modifying drugs (like methotrexate, sulfasalazine) is the most widely used form of corticosteroids administration in 30 % of patients. Corticosteroids in low-dose are able to decrease the radiographic progression of joint destruction. Low-dose of corticosteroids are generally well tolerated and no new osteoporotic fractures were found in the treated patients.

Key words:
Rheumatoid arthritis, corticosteroids therapy.


Sources

1. Bošmanský, K., Trnavský,K. Retrospektívny pohlad na použiti medikamentóznej liečby v skupine 100 chorých na reumatoidnú artritídu. Čas. lék. čes. 121, 1982, s. 95-97.

2. Caplan, L., Wolfe, F., Russell, A.S., Michaud, K. Corticosteroid use in rheumatoid arthritis: prevalence, predictors, correlates and outcomes. J. Rheumatol. 34, 2007, p. 696-706.

3. Everdingen, A.A., Jacobs, J.W., Siewerts, D.T. et al. Low-dose prednisone therapy for patients with early active rheumatoid arthritis. Ann. Int. Med. 136, 2002, p. 1-12.

4. Harris, E.D. Jr. Prednisolone in early rheumatoid arthritis: an antiinvasive effect. Arthr. Rheum. 52, 2005, p. 3324-3325.

5. Kirwan, J.R. The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The arthritis and rheumatism council low-dose glucocorticoid study group. New Engl. J. Med. 333, 1995, p. 142-146.

6. Saag, K.G., Koehnke, R.N., Caldwell, J.R. et al. Low-dose long term corticosteroid therapy in rheumatoid arthritis: An analysis of serious adverse events. Amer. J. Med. 1994, 96, p. 115-123.

7. Svensson, B., Boonen, A., Albertson, K. et al. Low-dose prednisolone in addition to the initial disease modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial. Arthr. Rheum. 52, 2005, p. 3360-3370.

8. Trnavský, K. Poznámky k použití kortikoidů v terapii revmatoidní artritidy. Rheumatologia 13, 1994, s. 177-180.

9. Wassenberg, S., Rau, R., Steinfeld, P., Zeidler, H. Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicentre, double-blind, placebo controlled trial. Arthr. Rheum. 52, 2005, p. 3371-3380.

Labels
General practitioner for children and adolescents General practitioner for adults
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#