Thyroxin binding globulin deficiency – a case study and literature review.

Czech version

Authors: A. Kreze jr. ¹; M. Pura ²; M. Kosák ¹; J. Koskuba ¹
Authors‘ workplace: II . Interní oddělení Fakultní nemocnice Bulovka, Praha Primář: MUDr. Jiří Koskuba. ¹; Národný endokrinologický a diabetologický ústav, Ľubochňa Primár: MUDr. Peter Vaňuga, Ph. D. ²
Published in: Prakt. Lék. 2008; 88(7): 425-426
Category: Case Report

Overview

Abnormalities in the serum proteins that transport thyroid hormones do not alter the metabolic state and do not cause thyroid disease. However, they do alter total thyroid hormone concentrations in serum and, when unrecognized, may lead to inappropriate treatment. Therefore, estimation of TSH and fT4 concentrations is usually all that is required for evaluation of thyroid function. Measurement of TBG and total hormones is only appropriate for special targets, and is not common practice.

Key words:
total thyroxine, free thyroxine, TBG, deficiency TBG.

Sources

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