Molecular cytogenetic approaches to bladder cancer diagnostics
Authors:
L. Housková 1; Z. Zemanová 1; L. Pavlištová 1; M. Pešl 2; M. Babjuk 2; K. Michalová 1
Authors‘ workplace:
Centrum nádorové cytogenetiky, Ústav klinické biochemie a laboratorní diagnostiky, Všeobecná fakultní nemocnice, Praha 2Urologická klinika, Všeobecná fakultní nemocnice, Praha Centrum nádorové cytogenetiky, Ústav klinické biochemie a laboratorní diagnosti
1
Published in:
Prakt. Lék. 2006; 86(4): 212-215
Category:
Diagnostis
Overview
There are many different types of bladder cancer in patients. They might be superficial, muscle invading and metastatic. Variability in bladder cancer forms is supposed to be influenced by various genetic alteration. Diagnostics is provided by various methods with different specificity and sensitivity. The higher sensitivity of the method is the sooner we can detect early genetic aberrations. These aberrations might be markers of oncoming reccurence as well as significant prognostic factor. The aim of this study was to summarize chromosomal aberrations in bladder cancer derived from transitional cells and to focus on the evaluation of qualitative and quantitative parametres of modern diagnostic methods. We included molecular-cytogenetic methods as a flow cytometry, FISH and CGH in comparison to commonly used cytology in this study.
Key words:
bladder cancer, flow cytometry, FISH, CGH, chromosomes
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2006 Issue 4
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