Obesity and kidney


Authors: V. Teplan 1–4;  M. Lukáš Jr 1,2;  P. Beňo 1,2;  M. Lukáš 1,2
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty a Centrum pro léčbu obezity ISCARE I. V. F. a. s., Praha 1;  1. LF UK, Praha 2;  Subkatedra nefrologie, Institut postgraduálního vzdělávání ve zdravotnictví, Praha 3;  Katedra interních oborů, LF OU, Ostrava 4
Published in: Gastroent Hepatol 2017; 71(6): 510-516
Category: Chapters from internal medicine: Review Article
doi: 10.14735/amgh2017510

Overview

Many studies have confirmed the close link between obesity and renal disease. Direct damage is caused by obesity-induced nephropathy, hypertension, and diabetes. The mechanism responsible for nephron damage has not yet been fully elucidated, but no doubt it involves hemodynamic, metabolic, and local inflammation factors.

Methods and Results:
Management focuses on controlling of hypertension, diabetes, and hyperlipidemia and, of course, restricting food energy intake and increasing physical activity. We prefer to use the least invasive methods to minimise internal environment disturbances. If these approaches are not successful, other methods must be used such as endoscopy and bariatric surgery. Due to potential risk of mineral and water disturbances, surgery management is indicated only in special case of serious obesity, mainly before kidney transplantation, but number of cases treated in this way is growing worldwide.

Conclusion:
It was repeatedly confirmed that in patients with a remarkable reduction of visceral fat mass, renal function was corrected, proteinuria decreased, hypertension and diabetes were better managed, and therefore their long-term well-being and life expectancy were also much better.

Key words:
obesity – nephropathy – diet – endoscopy – bariatric surgery

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
27. 9. 2017

Accepted:
23. 10. 2017


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Labels
Paediatric gastroenterology Gastroenterology and hepatology Surgery
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