Mesalazine in Crohn’s disease: obsolete or neglected treatment?

Authors: D. Ďuricová
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty, Iscare Lighthouse, Praha
Published in: Gastroent Hepatol 2013; 67(1): 22-24
Category: IBD: Review Article


Aminosalicylates have been used in the treatment of inflammatory bowel disease since the 1940s. These preparations are very effective in treatment of mild to moderate ulcerative colitis. However, their role in the treatment of Crohn’s disease is rather controversial. Several clinical studies and meta-analyses have so far failed to prove their efficacy in Crohn’s disease treatment. Subsequently, national and international guidelines did not recommend using aminosalicylates to treat Crohn’s disease. This article gives an overview of the role of aminosalicylates in Crohn’s disease and provides some evidence supporting the fact that aminosalicylates still have a place in the treatment of a certain group of patients with Crohn’s disease.

Key words:
sulfasalazine – mesalazine – Crohn’s disease – therapy

The author declares she has no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

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Paediatric gastroenterology Gastroenterology and hepatology Surgery
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