Diagnosis and therapy of celiac disease: today and tomorrow

Authors: M. Bátovský
Authors‘ workplace: Gastroenterologická klinika SZU a UNB, UN sv. Cyrila a Metoda, Bratislava
Published in: Gastroent Hepatol 2012; 66(5): 372-376
Category: Clinical and Experimental Gastroenterology: Review Article


Increased knowledge of non-invasive markers of celiac disease activity will hopefully enable better initial diagnosis and monitoring of intestinal damage (serological markers, galectin-10, cytokines). Additional celiac disease activity markers are being identified and new targets for treatment are being considered (P31–43 peptide, zonulin). Several new therapeutic approaches for celiac disease are currently under development by targeting its underlying pathogenesis. Alternative therapies range from reproduction of harmless wheat strains to immunomodulatory approaches. Some of these therapies, such as enzymatic cleavage of gluten and permeability inhibitors, have shown promise in clinical studies. Currently, adherence to a gluten-free diet is considered as the first line and indeed only therapy for celiac disease which has been proven to relieve symptoms in most cases and effectively prevent potential complications.

Key words:
celiac disease – gluten enteropathy – gluten-free diet – malabsorption syndrome

The author declares he has no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

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17. 7. 2012


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