Obesity paradox in patients with heart failure

Authors: Ján Murín 1;  Martin Wawruch 2;  Jozef Bulas 1;  František Mikla 1;  Soňa Kiňová 1
Authors‘ workplace: I. interná klinika LF UK a UNB, Nemocnica Staré Mesto, Bratislava 1;  Ústav farmakológie a klinickej farmakológie LF UK v Bratislave 2
Published in: Forum Diab 2018; 7(2): 105-107


Obesity and heart failure are nowadays frequent epidemics. If a young person (about 20–25 years old) is obese, it is in greater risk to be cardiovascularly ill (heart failure included) when being ≥ 50–60 years old in comparison with another non-obese person and it will also be at risk for development of type 2 diabetes when ≥ 50 years old. Basic research is able to explain these associations. Many years ago clinicians noticed that overweight/obese persons suffering a chronic cardiovascular (heart failure included) disease have a lower morbidity / mortality in comparison with a normal weight patients. The greatest morbidity / mortality risk is in low-weight (cachectic) patients. Authors try to explain this pathophysiology of „obesity paradox“. It is a “paradox“ in healthy persons, but in patients it is „obesity paradigm“.

Key words:

cardiovascular diseases heart failure obesity obesity paradox

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Diabetology Endocrinology Internal medicine
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