Hypoglycaemia in non-beta-cells tumours

Authors: Peter Galajda;  Marián Mokáň
Authors‘ workplace: I. interná klinika Jesseniovej LF UK a UNM, Martin
Published in: Forum Diab 2014; 3(1): 28-33
Category: Main Theme: Review


Non-beta-cells tumours are rare cause of hypoglycaemia. There are usually characterized such mesenchymal or epithelial tumours with huge size, slow growth and increased production of insulin like growth factor IGF2 (IGF2-oma). In non-beta-cells tumours there is present fasting hypoglycaemia associated with increased levels of total and free IGF2 as well as big IGF2 form. Due to suppression effect there are decreased levels of insulin, growth hormone and IGF1 and ratio IGF2/IGF1 is typically increased. Hypoglycaemia is caused by increased IGF2 levels and in the case of very huge tumours also by increased glucose utilization in tumour tissue. Attacks of hypoglycaemia may be diminished after successful treatment of primary non-beta-cells tumour.

Key words:
hypoglycaemia – IGF2 – insulin like growth factor 2 – non-beta-cells tumours


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Diabetology Endocrinology Internal medicine
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