Chromosomal Integration of the Sixth Human Herpes Virus (HHV-6)
Authors:
Hubáček Petr 1,2; Hrdličková Alena 2; Zajac Miroslav 1
Authors‘ workplace:
Ústav lékařské mikrobiologie 2. lékařské fakulty UK a Fakultní nemocnice v Motole
1; Klinika dětské hematologie a onkologie 2. lékařské fakulty UK a Fakultní nemocnice v Motole
2
Published in:
Epidemiol. Mikrobiol. Imunol. 61, 2012, č. 3, s. 58-66
Overview
Two closely related and commonly found human herpesviruses HHV-6 A and HHV-6 B are classified into the sixth human herpes virus complex (HHV-6). Primary infection with HHV-6 often takes place in early childhood and it can be either asymptomatic or manifests itself as sixth disease (caused by HHV-6 B). HHV-6 remains present in a latent form in the body with the potential for virus reactivation. The article points out the phenomenon of chromosomal integration of HHV‑6 (Ci-HHV-6) which is found in about 1% of the population and, unlike the commonly spread HHV-6 infection, has become hereditary, with its pathological potential in Ci-HHV-6 DNA carriers remaining unknown. Therefore, the focus on clinical consequences of Ci-HHV-6 is of high relevance to the therapeutic strategy for patients with high HHV-6 positivity in molecular biological tests.
Key words:
sixth human herpesvirus – molecular biology – PCR – chromosome
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Labels
Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
2012 Issue 3
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