#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
CS
proLékaře.cz / Journals / Czecho-Slovak Pathology / 2023 - 4

Composite follicular lymphoma and in situ mantle cell neoplasia of lymph node: identification based on flow cytometry investigation

Czech version

Authors: Tomáš Jirásek 1;  Marcela Mrhalová 2;  Tomáš Zajíc 3;  Miroslav Genský 4;  Tomáš Klinger 1;  Vít Campr 2
Authors‘ workplace: Oddělení patologie, Centrum PATOS, Krajská nemocnice Liberec, a. s. 1;  Ústav patologie a molekulární medicíny 2. LF UK a Fakultní nemocnice v Motole, Praha 2;  Oddělení molekulární genetiky a diagnostiky, Centrum PATOS, Krajská nemocnice Liberec, a. s. 3;  Oddělení klinické hematologie, Centrum laboratorní medicíny, Krajská nemocnice Liberec, a. s. 4
Published in: Čes.-slov. Patol., 59, 2023, No. 4, p. 177-183
Category: Original Article

Overview

The aim of the presented case report is to acquaint the wider professional public with a rare case of composite follicular lymphoma (FL) and in situ mantle cell neoplasia (ISMCN) in a lymph node. In both components, characteristics of tumor cells populations were investigated primarily using flow cytometry. The patient was diagnosed with a combination of composite FL grade 3A (FL-G3A) and ISMCN, this finding was also confirmed by histopathological and immunohistochemical examination of the lymph node and complemented by fluorescence in-situ hybridization (FISH). The described case shows the diagnostic difficulties in detecting this rare lesion and an important role of flow cytometry in diagnostics of lymphomas.

Keywords:

Flow cytometry – follicular lymphoma – Composite lymphoma – In-situ mantle cell neoplasia

Sources
  1. Kim H. Composite lymphoma and related disorders. American Journal of Clinical Pathology 1993; 99(4): 445–451.
  2. Wang E, Papavassiliou P, Wang RA, et al. Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases. Human Pathology 2014; 45: 768-784.
  3. Custer RP. Pitfalls in the diagnosis of lymphoma and leukemia from the pathologist‘s point of view. Proceedings of the Second National Cancer Conference, American Cancer Society 1954; 554-557.
  4. Vivian LF, Magnoli F, Campiotti L, et al. Composite follicular lymphoma and „early“ (in situ and mantle zone growth pattern) mantle cell neoplasia: A rare entity with peculiar cytogenetic and clinical features. Pathol Res Pract 2020; 216(9): 153067.
  5. Sabater-Marco V, Santonja-López N, Ortíz-Zuluaga S, et al. Orbital soft tissue composite lymphoma presenting as recurrence of a nodal lymphoma with mantle and follicular cell components: A case report, literature review and guideline for the treatment of patients. Rev Esp Patol 2020; 53(1): 48-54.
  6. Yuan J, Li S, Liu X, et al. Mantle Cell Lymphoma With Mantle Zone Growth Pattern. Am J Clin Pathol 2019; 152(2): 132-145.
  7. Tsang P, Pan L, Cesarman E, et al. A distinctive composite lymphoma consisting of clonally related mantle cell lymphoma and follicle center cell lymphoma. Human Pathology 1999; 30(8): 988–992.
  8. Looi A, Gascoyne RD, Chhanabhai M, et al. Mantle cell lymphoma in the ocular adnexal region. Ophthalmology 2005; 112(1):114–119.
  9. Zamò A, Zanotti R, Lestani M, et al. Molecular characterization of composite mantle cell and follicular lymphoma. Virchows Archiv 2006; 448(5): 639–643.
  10. Aqel N, Barker F, Patel K, et al. In-situ mantle cell lymphoma a report of two cases. Histopathology 2008; 52(2): 256–260.
  11. Ilgenfritz RB, Le Tourneau A, Arborio M et al. Composite mantle cell and follicular lymphoma. A case report. Human Pathology 2009; 40(2): 259–263.
  12. Roullet MR, Martinez D, Ma L et al. Coexisting follicular and mantle cell lymphoma with each having an in situ component: a novel, curious, and complex consultation case of coincidental, composite, colonizing lymphoma. American Journal of Clinical Pathology, 2010;133(4): 584–591.
  13. Wang S, Tzankov A, Xu-Monette ZY, et al. Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Hum Pathol 2013; 44(12): 2658-2667.
  14. Liu Y, Li P, Guo Y, et al. A unique composite follicular lymphoma and mantle cell lymphoma with a mixed cell pattern and aggressive course. American Journal of Clinical Pathology 2014; 141: 737–741.
  15. Marì-Jimenez P, Martinez-Losada C, Centeno-Haro M, et al. A rare composite lymphoma: follicular and in situ mantle cell. Annals of Hematology 2016; 95: 1351-1352.
  16. Subtil A, Xu Z. Follicular lymphoma with composite in situ mantle cell neoplasia. Blood 2019; 133(22): 2460.
  17. Matsuoka A, Tsushima T, Tanibuchi M, et al. Composite lymphoma consisting of mantle cell lymphoma and follicular lymphoma. The Japanese Journal of Clinical Hematology 2013; 54(11): 2056–2061.
  18. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue (Revised 4th edition). Lyon: IARC; 2017: 215-342.
Labels
Anatomical pathology Forensic medical examiner Toxicology
EDITORIAL
INTERVIEW
MONITOR
The role of flow cytometry in the diagnostics of pediatric haematologic and immunologic diseases
Flow cytometry immunophenotyping of the bone marrow samples for the diagnosis of hematologic neoplasms
The role of flow cytometry in the investigation of lymph node and extranodal lymphatic tissue specimen
Post-mortem examination of cases of sudden cardiac death. The Czech experience and the possibility of involving pathologists in a multidisciplinary process
Fat-poor spindle cell lipoma: a case report
Article was published in

Czecho-Slovak Pathology

Issue 4
2023 Issue 4
Most read in this issue
Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#