Precanceroses of the endometrium, fallopian tube and ovary: a review of current conception


Authors: P. Dundr
Authors‘ workplace: Ústav patologie 1. LF UK v Praze a VFN
Published in: Čes.-slov. Patol., 48, 2012, No. 1, p. 30-34
Category: Reviews Article

Overview

Recently, there has been a significant increase of knowledge regarding the pathogenesis and genetic changes occurring in carcinomas of the female genital tract and also regarding the definition of their precursors. A dualistic model of endometrial carcinogenesis has been accepted for a long period of time. Recently, a similar concept has been proposed for ovarian carcinomas. A correct definition of cancer precursors is important for the understanding of tumor pathogenesis. Moreover, it has an impact on the prevention and therapy of these tumors. In this review we summarize the precancers of the endometrium, fallopian tube and ovary according to the most recent advances in this research.

Keywords:
atypical endometrial hyperplasia – endometrial glandular dysplasia – endometrial intraepithelial carcinoma – p53 signature – tubal intraepithelial carcinoma


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