Post-Radiation Dedifferentiation of Meningioma into Chondroblastic Osteosarcoma


Authors: M. Švajdler ml.;  P. Bohuš;  B. Rychlý 1;  I. Šulla 2;  M. Moram 3
Authors‘ workplace: Oddelenie patológie, Fakultná nemocnica L. Pasteura, Košice ;  Cytopathos, s. r. o., Bratislava 1;  Neurochirurgická klinika, Fakultná nemocnica L. Pasteura, Košice 2;  Diagnostické centrum, s. r. o., Rimavská Sobota 3
Published in: Čes.-slov. Patol., 45, 2009, No. 1, p. 20-23
Category: Original Article

Overview

We report a case of post-radiation dedifferentiation of meningothelial meningioma into chondroblastic osteosarcoma. The tumor developed in a 61-year-old man, seven years after adjuvant stereotactical radiotherapy of recurring meningioma. Histologically, there was a continuous transition from atypical meningioma into chondroblastic osteosarcoma. The patient died three weeks after the surgery, without additional oncological treatment. To our knowledge, this case represents only the second reported case of post-radiation dedifferentiation of meningioma into osteosarcoma.

Key words:
meningioma – anaplastic meningioma – osteosarcoma – chondroblastic osteosarcoma – post-radiation sarcoma – dedifferentiation


Sources

1. Barresi, V., Cerasoli, S., Morigi, F., Cremonini, A.M., Volpini, M., Tuccari, G.: Gliosarcoma with features of osteoblastic osteosarcoma. Arch. Pathol. Lab. Med., 130, 2006, s. 1208–1211.

2. Carpentier, A.F., Chantelard, J.V., Henin, D., Poisson, M.: Osteosarcoma following radiation treatment for meningioma: report of a case and effective treatment with chemotherapy. J. Neurooncol., 21, 1994, s. 249–253.

3. Couldwell, W.T., Scheithauer, B.W., Rice, S.G., Zhang, W., Stillerman, C.B.: Osteosarcoma of the meninges in association with glioblastoma. Acta Neurochir., 139, 1997, s. 684–689.

4. Dagcinar, A.., Bayrakli, F., Yapicier, O., Ozek, M.: Primary meningeal osteosarcoma of the brain during childhood. J. Neurosurg. Pediatrics, 1, 2008, s. 325–329.

5. Hayashi, K., Ohara, N., Jeon, H.J. et al.: Gliosarcoma with features of chondroblastic osteosarcoma. Cancer, 72, 1993, s. 850–855.

6. Hussain, S., Nanada, A., Fowler, M., Ampil, F.L., Burton, G.V.: Primary intracranial leiomyosarcoma: Report of a case and review of the literature. Sarcoma, vol. 2006, Article ID 52140, 3 pages, 2006. doi:10.1155/SRCM/2006/52140.

7. Ironside, J.W., Moss, T.H., Louis, D.N., Lowe, J.S., Weller, R.O.: Meningiomas. In: Ironside, J.W., Moss, T.H., Louis, D.N., Lowe, J.S., Weller, R.O. Diagnostic pathology of nervous system tumours. Edinburgh: Churchill Livingstone, 2002, s. 343–382.

8. Kanazawa, R., Yoshida, D., Takahashi, H., Matsumoto, K., Teramoto, A.: Osteosarcoma arising from the skull. Neurol. Med. Chir., 43, 2003, s. 88–91.

9. Lam, R.M., Malik, G.M., Chason, J.L.: Osteosarcoma of meninges: clinical, light, and ultrastructural observations of a case. Am. J. Surg. Pathol., 5, 1981, s. 203–208.

10. Oliveira, A.M., Scheithauer, B.W., Salomao, D.R., Parisi, J.E., Burger, P.C., Nascimento, A.G.: Primary sarcomas of the brain and spinal cord. A study of 18 cases. Am. J. Surg. Pathol., 26, 2002, s. 1056–1063.

11. Osipov, V., Ho, K.C., Krouwer, H.G., Meyer, G., Shidham,V.B.: Post-radiation dedifferentiation of meningioma into osteosarcoma. BMC Cancer, 2, 2002, 34.

12. Perry, A.., Louis, D.N., Scheithauer, B.W., Budka, H., von Deimling, A.: Meningiomas. In: Louis, D.N., Ohgaki, H., Wiestler, O.T., Cavenee, W.K., ed. WHO classification of tumors. Pathology and genetics of tumors of the central nervous system. Lyon: IARC Press, 2007, s. 164–172.

13. Perry, A.: Meningiomas. In: McLendon, R., Rosenblum, M.K., Binger, D.D., ed. Russell and Rubinstein’s pathology of tumors of the nervous system. London: Hodder Arnold, 2006, s. 427–474.

14. Rodriguez, F.J., Scheithauer, B.W., Perry, A. et al.: Ependymal tumors with sarcomatous change (“Ependymosarcoma”): A clinicopathologic and molecular cytogenetic study. Am. J. Surg. Pathol., 32, 2008, s. 699–709.

15. Roncaroli, F., Scheithauer, B.W., Laeng, R.H., Cenacchi, G., Abell-Aleff, P., Moschopulos, M.: Lipomatous meningioma: a clinicopathologic study of 18 cases with special reference to the issue of metaplasia. Am. J. Surg. Pathol., 25, 2001, s. 769–775.

16. Tihan, T., Griffin, A., Özuysal, S.: Primary sarcomas of the central nervous system: UCSF experience (1985–2005). Turkish Journal of Pathology, 23, 2007, s. 5–15.

17. Walker, M.T., Toye, L.R., Coons, S.W., Porter, R.W., Wallace, R.C.: Intradural primary chondroblastic osteosarcoma: case report. Am. J. Neuroradiol., 22, 2001, s. 1960–1962.

18. Yamanouchi, H., Yokoo, H., Yoshida, T. et al.: Meshy meningioma: a potential novel variant. Neuropathology, 21, 2001, s. 236–240.

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