Anaplastic Carcinoma of the Thyroid Gland with Chondrosarcomatous Component

Czech version

Authors: J. Laco; A. Ryška; P. Čelakovský ^*
Authors‘ workplace: Fingerlandův ústav patologie, LF UK a FN, Hradec Králové ; Klinika ušní, nosní a krční, LF UK a FN, Hradec Králové ^*
Published in: Čes.-slov. Patol., 41, 2005, No. 1, p. 34-37
Category: Original Article

Overview

The case of an 83-year-old female with a history of a two months enlarging goiter is presented.

Clinically, a firm goiter with fixation to surrounding soft tissues was found. Fine needle aspiration cytology was performed with the conclusion of a sarcomatoid variant of anaplastic carcinoma of the thyroid gland; biopsy was recommended. The patient was operated on and died six months after operation with metastatic dissemination in lymphatic nodes and lungs.

Histologically, an invasive high-grade tumor composed of irregular, sometimes bizarre spindled or polygonal cells intermingled with foci of chondroid tissue was seen. The cartilage comprised lobularly arranged chondrocytes with irregular nuclei; bi- or multinucleated chondrocytes were present as well. The diagnosis of thyroid anaplastic carcinoma with chondrosarcomatous component was established. Differential diagnostics of this tumour is discussed.

Key words:
thyroid gland – anaplastic carcinoma – chondrosarcoma

Labels

Anatomical pathology Forensic medical examiner Toxicology

Acute Aortic Syndromes

The Role of the Extracellular Space in Biology of Glial Brain Tumors

Nervous Component of Mature Cystic Ovarian Teratomas

Acinic Cell-like Carcinoma and Acinic Cell-like Change in Ductal Hyperplasia of the Breast – Report of Two Cases

Article was published in

Czecho-Slovak Pathology

2005 Issue 1