Rare bullous diseases of childhood and their differential diagnosis

Czech version

Authors: Štěpánka Čapková
Authors‘ workplace: Dermatologické oddělení pro děti, Fakultní nemocnice Motol a Homolka, Praha
Published in: Čes-slov Pediat 2026; 81 (2): 71-77.
Category:
doi: https://doi.org/10.55095/CSPediatrie2026/009

Overview

Čapková Š. Rare bullous diseases of childhood and their differential diagnosis

Dermatologists as well as pediatricians are well aware that, due to its structural characteristics, the skin of infants and young children is prone to blister formation. Consequently, all of us encounter bullous conditions frequently (friction blisters, burns, solar dermatitis, bullous impetigo, diseases caused by herpes simplex virus or varicella-zoster virus). However, there are severe bullous disorders that are rare in childhood (autoimmune bullous diseases or certain genodermatoses), in which establishing the diagnosis requires extensive experience and expertise. In this presentation, the author introduces four rare bullous diseases and their clinical course in pediatric patients followed long term.

Keywords:

bullous diseases – differential diagnosis – pemphigus foliaceus – incontinentia pigmenti – diffuse cutaneous mastocytosis – lipoid proteinosis

Sources

1. Paller AS, Mancini AJ. Hurwitz Clinical Pediatric Dermatology. 6th ed. Elsevier 2022.

2. Harper J, Oranje A, Prose N. Textbook of Pediatric Dermatology. 2nd edition. Blackwell Publishing 2006.

3. Hercogová J, et al. Klinická dermatovenerologie. 1. díl. Praha: Mladá fronta 2019.

4. Bodemer C, Diociaiuti A, Hadj-Rabia S, et al. Multidisciplinary consensus recommendations from a European network for the diagnosis and practical management of patients with incontinentia pigmenti. J Eur Acad Dermatol Venereol 2020; 34(7): 1415–24.

5. Leguit RJ, Wang SA, George TI, et al. The international consensus classification of mastocytosis and related entities. Virchows Arch 2023; 482(1): 99–112.

6. Plzáková Z, Štork J, Mastocytózy. Čes-slov Dermatol 2018; 93(3): 91–100.

7. Kabre V, Rani S, Pai KM, Kamra S. Lipoid proteinosis: a review with two case reports. Contemp Clin Dent 2015; 6(2): 233–6.

8. Jedličková H. Autoimunitní puchýřnatá onemocnění: část I. Pemphigus. Čes-slov Dermatol 2022 : 144–215.