Bone Metabolism in Some Endocrinopathies

Overview

The authors investigated the osteoblastic and osteoclastic activity in female patients with Turner’s syndrome(TS) and in children with congenital adrenal hyperplasia. In 23 girls with TS they recorded low osteocalcin values(2.33 ± 1.34 ng/ml). The osteocalcin levels in healthy girls were 11.68 ± 7.74 ng/ml. After treatment with GH theosteoblastic activity increased, the osteocalcin level reached values of 16.9 ± 4.93 ng/ml, a further increase wasrecorded after combined treatment with GH and oestrogens. Then the osteocalcin level was 23.7 ± 3.66 ng/ml. Theosteoclastic activity did not change after GH treatment but after combined treatment with GH and oestrogens theauthors recorded a reduced excretion of pyridinoline and deoxypyridinoline (deoxypyridinoline before treatment40.50 ± 5.6 mmol/mmol creatinine, after treatment with GH only 42.60 ± 4.9, after combined treatment with GHand oestrogens 29.80 ± 3.5 mmol/mmol creatinine). In patients with CAH there was also a low osteocalcin level(1.41 ± 0.6 ng/ml) although porosity of bone tissue was not found. In these patients some part was played byandrogens which may be raised also during substitution and suppression treatment.

Key words:
osteoblastic activity, osteoclastic activity, Turner’s syndrome, congenital adrenal hyperplasia,treatment with growth hormone, treatment with oestrogens