Assessment of Crosslinks in Children from Overnight Urine - Diagnostic Index of Bone Resorption

Czech version

Authors: D. Mayerová ¹; A. Petříková ¹; A. Kolek ¹; J. Bartek ²
Authors‘ workplace: Dětská klinika LF UP a FN, Olomouc, 1přednosta doc. MUDr. V. Mihál, CSc. Oddělení klinické biochemie FN, Olomouc, 2přednosta doc. MUDr. J. Bartek, CSc.
Published in: Čes-slov Pediat 1999; (4): 212-216.
Category:

Overview

The authors present the results of pyridinoline (PYR) and deoxypyridinoline (DPYR) excretion in 179 healthychildren from infant age to adult age in the course of two years (1996 - 1998). They assessed reference values forage categories. In relation to the reference values the kinetics of PYR and DPYR (crosslinks) were assessed as wellas other markers in 68 patients treated on account of impaired bone metabolism, malabsorption, anorexia nervosa,coeliac disease, Crohn´s disease and rheumatic disease. Elevated urinary DPYR values correlated with reducedbone density and ICTP, ALP and PTH, osteocalcin. The authors recommend assessment of DPYR as a useful,non-invasive and rapid examination for evaluation of bone resorption and monitoring of therapy.

Key words:
deoxypyridinoline, pyridinoline, reference range in children, osteoporosis, bone resorption

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