Assessment of utility score EQ-D and estimating the Cost-utility of the first year of treatment by TNF inhibitors in a cohort of patients with Rheumatoid Arthritis during– results from the Czech biologics registry ATTRA

Authors: J. Závada 1;  M. Uher 2;  J. Jarkovský 2;  J. Vencovský 1,3;  K. Pavelka 1,3;  Kolektiv Lékařů Center Biologické Léčby
Authors‘ workplace: Revmatologický ústav, Praha 1;  Institut biostatistiky a analýz, Masarykova univerzita, Brno 2;  Česká revmatologická společnost JEP 3
Published in: Čes. Revmatol., 22, 2014, No. 1, p. 10-16.
Category: Original Papers


Utility scores are used as an input parameter for Quality Adjusted Life Years (QALYs) calculations in cost-utility analyses. Our aim was to evaluate the changes in utility score assessed by the EuroQOL-5D (EQ-5D) instrument during one year of the first-line treatment with TNF inhibitors (Etanercept, Adalimumab, Infliximab) in patients with rheumatoid arthritis (RA).

Patients and methods:
823 RA patients with available clinical data (DAS28, HAQ), and health-related quality of life (HRQOL) data (EQ-5D) completing one year treatment were included in the analysis.

In the analyzed sample there were 82 % females, median age was 51 years (IQR 41–58) and median disease duration of 7 years (IQR 3–13) at the beginning of anti-TNF therapy. 28 % were treated by infliximab, 46 % by adalimumab, and 26 % by etanercept. Patients’ QoL improved during the treatment—utility increased from a median of 0.16 to 0.69, and clinically meaningful improvements in EQ-5D were observed in 61 % of patients.

Most patients with RA experienced clinically important improvements in HRQOL during the first year of treatment by TNF inhibitors. For this patient group, cost-utility ratios were within the recommended limits acceptable for payers of health care.

Key words:
Health-related quality of life, biologic disease-modifying anti-rheumatic drugs, anti-tumour necrosis factor drugs, rheumatoid arthritis, registry, EQ-5D


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Dermatology & STDs Paediatric rheumatology Rheumatology
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