Health Related quality of life in patients with rheumatoid arthritis during the first year of treatment by TNF inhibitors (assessed by SF-36 questionnaire and compared with a sample of general Czech population) – results from the Czech biologics registry ATTRA

Authors: J. Závada 1;  M. Uher 2;  K. Hejduk 2;  J. Vencovský 3,1;  K. Pavelka 1,3;  Kolektiv Lékařů Biologických Center
Authors‘ workplace: Revmatologický ústav, Praha 1;  Institut biostatistiky a analýz, Masarykova univerzita, Brno 2;  Česká revmatologická společnost JEP 3
Published in: Čes. Revmatol., 21, 2013, No. 3, p. 123-130.
Category: Original Papers


Health-related quality of life (HRQOL) is an important indicator of severity of musculoskeletal conditions. SF-36 is a generic patient-reported measure of HRQOL implemented in the follow-up protocol of the ATTRA registry. Our goal was to assess HRQOL (as measured by SF-36 and its individual domains) before and after first-line treatment with TNF inhibitors (Etanercept, Adalimumab, Infliximab) in patients with rheumatoid arthritis, and to compare the results with age-adjusted normative values of general Czech population.

Patients and methods:
823 RA patients with available clinical data (DAS28, HAQ), and HRQOL data (SF-36) completing one year tratment were included in the analysis.

In the analyzed sample there were 82 % females and 18 % males with median age of 51 years (IQR 41-58) and median disease duration of 7 years (IQR 3-13) at the beginning of anti-TNF therapy. 28 % were treated by infliximab, 46 % by adalimumab, and 26 % by etanercept. Clinically meaningful and statistically significant improvements were observed in all dimensions of HRQOL assessed by SF-36, and in the mental health domain the RA patients reached similar scores as individuals from the age-standardized sample of general Czech population.

RA had a severe impact on all dimensions of HRQOL. During one year of treatment, TNF-inhibitors substantially improved HRQOL, though not to the normal level.

Key words:
Health-related quality of life, SF-36, biologic disease-modifying anti-rheumatic drugs, anti-tumour necrosis factor drugs, rheumatoid arthritis, registry


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Dermatology & STDs Paediatric rheumatology Rheumatology
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